Platinum catalysed hydrolytic amidation of unactivated nitriles

被引：101

作者：

Cobley, CJ ^{[1
]}

van den Heuvel, M ^{[1
]}

Abbadi, A ^{[1
]}

de Vries, JG ^{[1
]}

机构：

[1] DSM Res BV, Dept Fine Chem, NL-6160 MD Geleen, Netherlands

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 14期

关键词：

homogeneous catalysis; nitriles; amides; platinum compounds;

D O I：

10.1016/S0040-4039(00)00181-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The platinum(II) complex, [(Me2PO .. H .. OPMe2)PtH(PMe2OH)], efficiently catalyses the direct conversion of unactivated nitriles to N-substituted amides with both primary and secondary amines. Possible mechanisms for this reaction are discussed and evidence for initial amidine formation is reported. Isolated yields vary from 51-89%. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2467 / 2470

页数：4

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