Population pharmacokinetics/pharmacodynamics modeling: Parametric and nonparametric methods

被引：36

作者：

Jelliffe, R ^{[1
]}

Schumitzky, A ^{[1
]}

Van Guilder, M ^{[1
]}

机构：

[1] Univ So Calif, Sch Med, Div Geriatr Med, Lab Appl Pharmacokinet, Los Angeles, CA 90033 USA

来源：

THERAPEUTIC DRUG MONITORING | 2000年 / 22卷 / 03期

关键词：

population pharmacokinetic modeling; pharmacodynamic modeling; parametric methods; nonparametric methods;

D O I：

10.1097/00007691-200006000-00019

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

As clinicians acquire experience with the clinical and pharmacokinetic behavior of a drug, it is usually optimal to record this experience in the form of a population pharmacokinetic model, and then to relate the behavior of the model to the clinical effects of the drug or to a linked pharmacodynamic model. The role of population modeling is thus to describe and record clinical experience with the behavior of a drug in a certain group or population of patients or subjects.

引用

页码：354 / 365

页数：12

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