Enantioselective modification of the Pomeranz-Fritsch-Bobbitt synthesis of tetrahydroisoquinoline alkaloids: synthesis of (-)-salsolidine and (-)-carnegine

被引：28

作者：

Gluszynska, A ^{[1
]}

Rozwadowska, MD ^{[1
]}

机构：

[1] Adam Mickiewicz Univ, Fac Chem, PL-60780 Poznan, Poland

来源：

TETRAHEDRON-ASYMMETRY | 2000年 / 11卷 / 11期

关键词：

D O I：

10.1016/S0957-4166(00)00196-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

(-)-Salsolidine 7 and (-)-carnegine 8 were prepared in 46 and 36% e.e., respectively, by enantioselective addition of methyllithium to the Pomeranz-Fritsch imine 13 in the presence of ligands 9 12, followed by acid-catalyzed cyclization and hydrogenolysis. (C) 2000 Elsevier Science Ltd, All rights reserved.

引用

页码：2359 / 2366

页数：8

共 29 条

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