Cognitive deficits in spinocerebellar ataxia type 1, 2, and 3

被引：164

作者：

Bürk, K

Globas, C

Bösch, S

Klockgether, T

Zühlke, C

Daum, I

Dichgans, J

机构：

[1] Univ Tubingen, Dept Neurol, D-72076 Tubingen, Germany

[2] Univ Bonn, Dept Neurol, D-5300 Bonn, Germany

来源：

JOURNAL OF NEUROLOGY | 2003年 / 250卷 / 02期

关键词：

spinocerebellar ataxia; cerebellum; cognition; executive dysfunction;

D O I：

10.1007/s00415-003-0976-5

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cognitive impairment was studied in distinct types of spinocerebellar ataxia (SCA): eleven SCA 1, 14 SCA2, and 11 SCA3 individuals and 8 age- and IQ-matched controls. All were submitted to a neuropsychological test battery that comprised tests for IQ, attention, executive function, verbal and visuospatial memory. Executive dysfunction was prominent in SCA1 as compared with controls and all other SCA types. Mild deficits of verbal memory were present in SCA1, SCA2 and SCA3. The neuropathological pattern in different SCA types suggests that these cognitive deficits are not likely to be contingent upon cerebellar degeneration but to result from disruption of a cerebrocerebellar circuitry presumably at the pontine level.

引用

页码：207 / 211

页数：5

共 43 条

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