Motor reorganization in multiple sclerosis

被引:17
作者
Wang, Jun
Hier, Daniel B.
机构
[1] Univ Illinois, Dept Bioengn, Chicago, IL 60612 USA
[2] Univ Illinois, Dept Neurol & Rehabil, Chicago, IL 60612 USA
关键词
cortical plasticity; functional MRI; motor reorganization; motor systems; multiple sclerosis;
D O I
10.1179/174313206X153833
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: To assess intra-hemispheric and interhemispheric reorganization of motor activation in multiple sclerosis ( MS). Motor reorganization may contribute to minimizing motor deficits after demyelination in MS. Methods: We used surface-based analysis to study functional organization for motor function in ten healthy controls and in 15 MS subjects. Results and discussion: In MS subjects, activation in the right hemisphere ( ipsilateral to the hand moved) was significantly increased compared with control subjects. We interpreted this increase as interhemispheric reorganization of motor activation. The increases in right hemisphere activation were the greatest in the pre-motor cortex ( Brodmann area 6) and the cognitive areas. Within the left hemisphere, contralateral to the right hand, total motor activation was not increased and the centroid of activation was not displaced when MS subjects were compared with controls. However, we found that MS subjects with high MS plaque loads showed an anterior shift of the focus of motor activation with right hand movement when compared with the low MS plaque load subjects ( p < 0.05). Furthermore, there was more activation in pre-motor cortex ( Brodmann area 6) in the high plaque load group and less activation in sensory areas ( Brodmann areas 1, 2 and 3). Conclusion: Functional magnetic resonance imaging ( fMRI) provides evidence that both interhemispheric and intra-hemispheric motor reorganization occur in MS.
引用
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页码:3 / 8
页数:6
相关论文
共 11 条
[1]   LOCALIZATION OF BRAIN-FUNCTION USING MAGNETIC-RESONANCE-IMAGING [J].
COHEN, MS ;
BOOKHEIMER, SY .
TRENDS IN NEUROSCIENCES, 1994, 17 (07) :268-277
[2]   Cortical reorganisation in patients with MS [J].
Filippi, M ;
Rocca, MA .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2004, 75 (08) :1087-1089
[3]   Correlations between structural CNS damage and functional MRI changes in primary progressive MS [J].
Filippi, M ;
Rocca, MA ;
Falini, A ;
Caputo, D ;
Ghezzi, A ;
Colombo, B ;
Scotti, G ;
Comi, G .
NEUROIMAGE, 2002, 15 (03) :537-546
[4]  
Lee M, 2000, ANN NEUROL, V47, P606, DOI 10.1002/1531-8249(200005)47:5<606::AID-ANA8>3.3.CO
[5]  
2-C
[6]  
PATANO P, 2002, BRAIN, V125, P1607
[7]   A functional magnetic resonance imaging study of patients with secondary progressive multiple sclerosis [J].
Rocca, MA ;
Gavazzi, C ;
Mezzapesa, DM ;
Falini, A ;
Colombo, B ;
Mascalchi, M ;
Scotti, G ;
Comi, G ;
Filippi, M .
NEUROIMAGE, 2003, 19 (04) :1770-1777
[8]   Evidence for widespread movement-associated functional MRI changes in patients with PPMS [J].
Rocca, MA ;
Matthews, PM ;
Caputo, D ;
Ghezzi, A ;
Falini, A ;
Scotti, G ;
Comi, G ;
Filippi, M .
NEUROLOGY, 2002, 58 (06) :866-872
[9]   Adaptive functional changes in the cerebral cortex of patients with nondisabling multiple sclerosis correlate with the extent of brain structural damage [J].
Rocca, MA ;
Falini, A ;
Colombo, B ;
Scotti, G ;
Comi, G ;
Filippi, M .
ANNALS OF NEUROLOGY, 2002, 51 (03) :330-339
[10]   An integrated software suite for surface-based analyses of cerebral cortex [J].
Van Essen, DC ;
Drury, HA ;
Dickson, J ;
Harwell, J ;
Hanlon, D ;
Anderson, CH .
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION, 2001, 8 (05) :443-459