Studies of the serum HER-2/neu and squamous cell carcinoma-related antigen expression in patients with oral squamous cell carcinoma

被引：9

作者：

Chen, Chung-Ho

Tsai, Tsung Lin

Yang, Yi-Shin

Tsai, Chi-Cheng

机构：

[1] Kaohsiung Med Univ, Chung Ho Mem Hosp, Dept Oral Maxillofacial Surg, Kaohsiung 807, Taiwan

[2] Kaohsiung Med Univ, Chung Ho Mem Hosp, Grad Inst Dent Sci, Kaohsiung 807, Taiwan

[3] Kaohsiung Med Univ, Chung Ho Mem Hosp, Grad Inst Oral Hlth Sci, Kaohsiung 807, Taiwan

[4] Kaohsiung Med Univ, Chung Ho Mem Hosp, Dept Periodontol, Kaohsiung 807, Taiwan

来源：

JOURNAL OF ORAL PATHOLOGY & MEDICINE | 2007年 / 36卷 / 02期

关键词：

HER-2/neu; OSCC; SCCA;

D O I：

10.1111/j.1600-0714.2007.00502.x

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

BACKGROUND: Over-expression of HER-2/neu has been associated with advanced disease, metastasis, and poor clinical outcome. Squamous cell carcinoma (SCC)-related antigen (SCCA) is used as a tumor marker in a variety of SCC. This study was performed to investigate the pre- and post-treatment values of HER-2/neu and SCCA in patients with oral SCC. MATERIALS: Patients with OSCC were enrolled between 2002 and 2004. Serum samples were obtained before treatment and at 1 month following treatment. HER-2/neu levels and SCCA levels were determined by enzyme-linked immunosorbent assay and radioimmunoassay, respectively. RESULTS: A significant correlation was found between HER-2/neu and lymph node metastasis (P = 0.0252). SCCA correlated with tumor size (P = 0.0042). Both HER-2/neu and SCCA mean levels were reduced significantly after treatment. CONCLUSION: The combination of HER-2/neu and SCCA serum levels may be a useful marker in evaluating therapeutic effects and in monitoring the recurrence rate of OSCC and survival rate of patients.

引用

页码：83 / 87

页数：5

共 30 条

[1] THE PRODUCT OF THE HUMAN C-ERBB-2 GENE - A 185-KILODALTON GLYCOPROTEIN WITH TYROSINE KINASE-ACTIVITY [J].