The gene for human IL-21 and genetic susceptibility to type 1 diabetes in the Japanese

被引：9

作者：

Asano, Katsuaki

Ikegami, Hiroshi

Fujisawa, Tomomi

Kawabata, Yumiko

Noso, Shinsuke

Hiromine, Yoshihisa

Ogihara, Toshio

机构：

[1] Kinki Univ, Sch Med, Dept Endocrinol Diabet & Metab, Sayama, Osaka 5898511, Japan

[2] Osaka Univ, Grad Sch Med, Dept Geriat Med, Suita, Osaka 5650871, Japan

来源：

IMMUNOLOGY OF DIABETES IV: PROGRESS IN OUR UNDERSTANDING | 2006年 / 1079卷

关键词：

type; 1; diabetes; interleukin-21; genetics; autoimmune disease;

D O I：

10.1196/annals.1375.007

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Type 1 diabetes is under polygenic control both in humans and the NOD mouse. Recently a possible role of IL-21 in the pathogenesis of type 1 diabetes was demonstrated in the NOD mouse. Furthermore, the murine IL-21 gene is mapped to the Idd3 interval, making the human IL-21 gene (IL21) a functional as well as positional candidate for susceptibility. We therefore screened sequence variants of IL21 and studied the association with type 1 diabetes. Preliminary data showed no association of IL21 polymorphisms with the disease, suggesting that IL21 plays little role in susceptibility to type 1 diabetes in Japanese.

引用

页码：47 / 50

页数：4

共 7 条

[1]

Genetics of insulin-dependent diabetes mellitus [J].

Ikegami, H ;

Ogihara, T .

ENDOCRINE JOURNAL, 1996, 43 (06) :605-613

[2]

Asian-specific HLA haplotypes reveal heterogeneity of the contribution of HLA-DR and -DQ haplotypes to susceptibility to type 1 diabetes [J].

Kawabata, Y ;

Ikegami, H ;

Kawaguchi, Y ;

Fujisawa, T ;

Shintani, M ;

Ono, M ;

Nishino, M ;

Uchigata, Y ;

Lee, I ;

Ogihara, T .

DIABETES, 2002, 51 (02) :545-551

[3]

Homeostatic expansion of T cells during immune insufficiency generates autoimmunity [J].

King, C ;

Ilic, A ;

Koelsch, K ;

Sarvetnick, N .

CELL, 2004, 117 (02) :265-277

[4]

Interleukin-21: A modulator of lymphoid proliferation, apoptosis and differentiation [J].

Leonard, WJ ;

Spolski, R .

NATURE REVIEWS IMMUNOLOGY, 2005, 5 (09) :688-698

[5]

Congenic mapping of the type 1 diabetes locus, ldd3, to a 780-kb region of mouse chromosome 3:: Identification of a candidate segment of ancestral DNA by haplotype mapping [J].

Lyons, PA ;

Armitage, N ;

Argentina, F ;

Denny, P ;

Hill, NJ ;

Lord, CJ ;

Wilusz, MB ;

Peterson, LB ;

Wicker, LS ;

Todd, JA .

GENOME RESEARCH, 2000, 10 (04) :446-453

[6]

Functional polymorphism in Z-DNA-forming motif of promoter of SLC11A1 gene and type 1 diabetes in Japanese subjects:: Association study and meta-analysis [J].

Nishino, M ;

Ikegami, H ;

Fujisawa, T ;

Kawaguchi, Y ;

Kawabata, Y ;

Shintani, M ;

Ono, M ;

Ogihara, T .

METABOLISM-CLINICAL AND EXPERIMENTAL, 2005, 54 (05) :628-633

[7]

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease [J].

Ueda, H ;

Howson, JMM ;

Esposito, L ;

Heward, J ;

Snook, H ;

Chamberlain, G ;

Rainbow, DB ;

Hunter, KMD ;

Smith, AN ;

Di Genova, G ;

Herr, MH ;

Dahlman, I ;

Payne, F ;

Smyth, D ;

Lowe, C ;

Twells, RCJ ;

Howlett, S ;

Healy, B ;

Nutland, S ;

Rance, HE ;

Everett, V ;

Smink, LJ ;

Lam, AC ;

Cordell, HJ ;

Walker, NM ;

Bordin, C ;

Hulme, J ;

Motzo, C ;

Cucca, F ;

Hess, JF ;

Metzker, ML ;

Rogers, J ;

Gregory, S ;

Allahabadia, A ;

Nithiyananthan, R ;

Tuomilehto-Wolf, E ;

Tuomilehto, J ;

Bingley, P ;

Gillespie, KM ;

Undlien, DE ;

Ronningen, KS ;

Guja, C ;

Ionescu-Tirgoviste, C ;

Savage, DA ;

Maxwell, AP ;

Carson, DJ ;

Patterson, CC ;

Franklyn, JA ;

Clayton, DG ;

Peterson, LB .

NATURE, 2003, 423 (6939) :506-511

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