Production of macrophage inflammatory protein 3α (MIP-3α) (CCL20) and MIP-3β (CCL19) by human peripheral blood neutrophils in response to microbial pathogens

被引：32

作者：

Akahoshi, T

Sasahara, T

Namai, R

Matsui, T

Watabe, H

Kitasato, H

Inoue, M

Kondo, H

机构：

[1] Kitasato Univ, Sch Med, Dept Lab Med, Sagamihara, Kanagawa 2288555, Japan

[2] Kitasato Univ, Sch Med, Dept Microbiol, Sagamihara, Kanagawa 2288555, Japan

[3] Kitasato Univ, Sch Med, Dept Internal Med, Sagamihara, Kanagawa 2288555, Japan

来源：

INFECTION AND IMMUNITY | 2003年 / 71卷 / 01期

关键词：

D O I：

10.1128/IAI.71.1.524-526.2003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Effects of bacterial pathogens on the production of macrophage inflammatory protein 3alpha (MIP-3alpha) and MIP-3beta from human peripheral blood neutrophils were investigated. Neutrophils produced both chemokines by coincubation with either gram-positive or gram-negative bacteria. Neutrophils may initiate antigen-specific immune responses through the release of these chemokines that are capable of promoting selective recruitment of dendritic cells and T-cell subsets.

引用

页码：524 / 526

页数：3

共 17 条

[1] Regulated production of the interferon-gamma-inducible protein-10 (IP-10) chemokine by human neutrophils [J].