Production of macrophage inflammatory protein 3α (MIP-3α) (CCL20) and MIP-3β (CCL19) by human peripheral blood neutrophils in response to microbial pathogens

被引:32
作者
Akahoshi, T
Sasahara, T
Namai, R
Matsui, T
Watabe, H
Kitasato, H
Inoue, M
Kondo, H
机构
[1] Kitasato Univ, Sch Med, Dept Lab Med, Sagamihara, Kanagawa 2288555, Japan
[2] Kitasato Univ, Sch Med, Dept Microbiol, Sagamihara, Kanagawa 2288555, Japan
[3] Kitasato Univ, Sch Med, Dept Internal Med, Sagamihara, Kanagawa 2288555, Japan
关键词
D O I
10.1128/IAI.71.1.524-526.2003
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Effects of bacterial pathogens on the production of macrophage inflammatory protein 3alpha (MIP-3alpha) and MIP-3beta from human peripheral blood neutrophils were investigated. Neutrophils produced both chemokines by coincubation with either gram-positive or gram-negative bacteria. Neutrophils may initiate antigen-specific immune responses through the release of these chemokines that are capable of promoting selective recruitment of dendritic cells and T-cell subsets.
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收藏
页码:524 / 526
页数:3
相关论文
共 17 条
[1]   Regulated production of the interferon-gamma-inducible protein-10 (IP-10) chemokine by human neutrophils [J].
Cassatella, MA ;
Gasperini, S ;
Calzetti, F ;
Bertagnin, A ;
Luster, AD ;
McDonald, PP .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1997, 27 (01) :111-115
[2]   Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites [J].
Dieu, MC ;
Vanbervliet, B ;
Vicari, A ;
Bridon, JM ;
Oldham, E ;
Aït-Yahia, S ;
Brière, F ;
Zlotnik, A ;
Lebecque, S ;
Caux, C .
JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (02) :373-386
[3]   Regulation of dendritic cell trafficking: a process that involves the participation of selective chemokines [J].
Dieu-Nosjean, MC ;
Vicari, A ;
Lebecque, S ;
Caux, C .
JOURNAL OF LEUKOCYTE BIOLOGY, 1999, 66 (02) :252-262
[4]  
Gasperini S, 1999, J IMMUNOL, V162, P4928
[5]   CCR6, a CC chemokine receptor that interacts with macrophage inflammatory protein 3 alpha and is highly expressed in human dendritic cells [J].
Greaves, DR ;
Wang, W ;
Dairaghi, DJ ;
Dieu, MC ;
deSaintVis, B ;
FranzBacon, K ;
Rossi, D ;
Caux, C ;
McClanahan, T ;
Gordon, S ;
Zlotnik, A ;
Schall, TJ .
JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 186 (06) :837-844
[6]  
Hachicha M, 1998, J IMMUNOL, V160, P449
[7]  
Rossi DL, 1997, J IMMUNOL, V158, P1033
[8]   Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responses [J].
Sallusto, F ;
Lanzavecchia, A ;
Mackay, CR .
IMMUNOLOGY TODAY, 1998, 19 (12) :568-574
[9]  
Scapini P, 2001, EUR J IMMUNOL, V31, P1981, DOI 10.1002/1521-4141(200107)31:7<1981::AID-IMMU1981>3.3.CO
[10]  
2-O