Plasma cell toll-like receptor (TLR) expression differs from that of B cells, and plasma cell TLR triggering enhances immunoglobulin production

被引：87

作者：

Dorner, Marcus ^{[1
,2
]}

Brandt, Simone ^{[1
,2
]}

Tinguely, Marianne ^{[3
]}

Zucol, Franziska ^{[1
,2
]}

Bourquin, Jean-Pierre ^{[4
]}

Zauner, Ludwig ^{[1
,2
]}

Berger, Christoph ^{[1
,2
]}

Bernasconi, Michele ^{[1
,2
]}

Speck, Roberto F. ^{[5
,6
]}

Nadal, David ^{[1
,2
]}

机构：

[1] Univ Childrens Hosp Zurich, Div Infect Dis, CH-8057 Zurich, Switzerland

[2] Univ Childrens Hosp Zurich, Hosp Epidemiol, CH-8057 Zurich, Switzerland

[3] Univ Childrens Hosp Zurich, Div Oncol Expt Infect Dis & Canc Res, CH-8057 Zurich, Switzerland

[4] Univ Zurich Hosp, Inst Surg Pathol, Dept Pathol, CH-8091 Zurich, Switzerland

[5] Univ Zurich Hosp, Div Infect Dis, CH-8091 Zurich, Switzerland

[6] Univ Zurich Hosp, Hosp Epidemiol, CH-8091 Zurich, Switzerland

来源：

IMMUNOLOGY | 2009年 / 128卷 / 04期

基金：

瑞士国家科学基金会;

关键词：

B-cell subpopulations; immunoglobulin production; mRNA expression; plasma cells; toll-like receptors; BARR-VIRUS INFECTION; MESSENGER-RNA; ACTIVATION; DIFFERENTIATION; PERIODONTITIS; REPERTOIRE; IMMUNITY; SUBSETS;

D O I：

10.1111/j.1365-2567.2009.03143.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

P>Toll-like receptors (TLRs) are key receptors of the innate immune system and show cell subset-specific expression. We investigated the messenger RNA (mRNA) expression of TLR genes in human haematopoietic stem cells (HSC), in naive B cells, in memory B cells, in plasma cells from palatine tonsils and in plasma cells from peripheral blood. HSC and plasma cells showed unrestricted expression of TLR1-TLR9, in contrast to B cells which lacked TLR3, TLR4 and TLR8 but expressed mRNA of all other TLRs. We demonstrated, for the first time, that TLR triggering of terminally differentiated plasma cells augments immunoglobulin production. Thus, boosting the immediate antibody response by plasma cells upon pathogen recognition may point to a novel role of TLRs.

引用

页码：573 / 579

页数：7

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