Biology of Castration-Recurrent Prostate Cancer

被引：33

作者：

Azzouni, Faris ^{[1
]}

Mohler, James ^{[1
]}

机构：

[1] Roswell Pk Canc Inst, Dept Urol, Buffalo, NY 14263 USA

来源：

UROLOGIC CLINICS OF NORTH AMERICA | 2012年 / 39卷 / 04期

关键词：

Prostate cancer; Castration resistant; Castration recurrent; Biology; Mechanism; ANDROGEN-RECEPTOR GENE; EPIDERMAL-GROWTH-FACTOR; LIGAND-BINDING DOMAIN; CIRCULATING TUMOR-CELLS; HUMAN LNCAP CELLS; NUCLEAR RECEPTOR; DEPRIVATION THERAPY; INDEPENDENT GROWTH; IN-VIVO; TYROSINE PHOSPHORYLATION;

D O I：

10.1016/j.ucl.2012.07.002

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

100201 [内科学]; 100221 [泌尿外科学];

摘要：

Although androgen-deprivation therapy is the standard therapy for advanced and metastatic prostate cancer, this treatment is only palliative. Prostate cancer recurs then grows despite low circulating testicular androgens, using several mechanisms that remain dependent on androgen-receptor signaling in most cases. This article reviews the diversity of mechanisms used for growth by castration-recurrent prostate cancer.

引用

页码：435 / +

页数：19

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