Cigarette smoking and pancreatic cancer: an analysis from the International Pancreatic Cancer Case-Control Consortium (Panc4)

被引：321

作者：

Bosetti, C. ^{[1
,2
]}

Lucenteforte, E. ^{[1
,3
,4
]}

Silverman, D. T. ^{[5
]}

Petersen, G. ^{[6
]}

Bracci, P. M. ^{[7
]}

Ji, B. T. ^{[5
]}

Negri, E. ^{[1
]}

Li, D. ^{[8
]}

Risch, H. A. ^{[9
]}

Olson, S. H. ^{[10
]}

Gallinger, S. ^{[11
]}

Miller, A. B. ^{[12
]}

Bueno-de-Mesquita, H. B. ^{[13
,14
]}

Talamini, R. ^{[15
]}

Polesel, J. ^{[15
]}

Ghadirian, P. ^{[16
]}

Baghurst, P. A. ^{[17
]}

Zatonski, W. ^{[18
,19
]}

Fontham, E. ^{[20
]}

Bamlet, W. R. ^{[6
]}

Holly, E. A. ^{[7
]}

Bertuccio, P. ^{[1
,3
]}

Gao, Y. T. ^{[21
]}

Hassan, M. ^{[8
]}

Yu, H. ^{[10
]}

Kurtz, R. C. ^{[22
]}

Cotterchio, M. ^{[12
,23
]}

Su, J. ^{[5
]}

Maisonneuve, P. ^{[24
]}

Duell, E. J. ^{[25
]}

Boffetta, P. ^{[26
,27
,28
]}

La Vecchia, C. ^{[1
,3
,28
]}

机构：

[1] Ist Ric Farmacol Mario Negri, Dept Epidemiol, I-2056 Milan, Italy

[2] Maastricht Univ, Dept Complex Genet, Cluster Genet & Cell Biol, NUTRIM Sch Nutr Toxicol & Metab,Med Ctr, Maastricht, Netherlands

[3] Univ Milan, Dept Occupat Hlth, Milan, Italy

[4] Univ Florence, Dept Preclin & Clin Pharmacol Mario Aiazzi Mancin, Florence, Italy

[5] NCI, Bethesda, MD 20892 USA

[6] Mayo Clin, Rochester, MN USA

[7] Univ Calif San Francisco, San Francisco, CA 94143 USA

[8] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

[9] Yale Univ, Sch Med, Dept Epidemiol & Publ Hlth, New Haven, CT 06510 USA

[10] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA

[11] Toronto Gen Hosp, Toronto, ON, Canada

[12] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada

[13] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[14] Univ Med Ctr Utrecht, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[15] Natl Canc Inst, Unit Epidemiol & Biostat, Ctr Riferimento Oncol, Aviano, Italy

[16] Res Ctr CRCHUM, Epidemiol Res Unit, Montreal, PQ, Canada

[17] Womens & Childrens Hosp, Adelaide, SA, Australia

[18] Ctr Canc, Warsaw, Poland

[19] Inst Oncol, Warsaw, Poland

[20] Louisiana State Univ, Sch Publ Hlth, New Orleans, LA USA

[21] Shanghai Canc Inst, Shanghai, Peoples R China

[22] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10021 USA

[23] Canc Care Ontario, Toronto, ON, Canada

[24] European Inst Oncol, Milan, Italy

[25] Catalan Inst Oncol, Barcelona, Spain

[26] Mt Sinai Sch Med, Tisch Canc Inst, New York, NY USA

[27] Mt Sinai Sch Med, Inst Translat Epidemiol, New York, NY USA

[28] Int Prevent Res Inst, Lyon, France

来源：

ANNALS OF ONCOLOGY | 2012年 / 23卷 / 07期

基金：

美国国家卫生研究院;

关键词：

case-control study; cigarette smoking; pancreatic cancer; pooled analysis; RISK; TOBACCO; NITROSAMINES; METAANALYSIS; CONSUMPTION; ALCOHOL;

D O I：

10.1093/annonc/mdr541

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

To evaluate the dose-response relationship between cigarette smoking and pancreatic cancer and to examine the effects of temporal variables. We analyzed data from 12 case-control studies within the International Pancreatic Cancer Case-Control Consortium (PanC4), including 6507 pancreatic cases and 12 890 controls. We estimated summary odds ratios (ORs) by pooling study-specific ORs using random-effects models. Compared with never smokers, the OR was 1.2 (95% confidence interval [CI] 1.0-1.3) for former smokers and 2.2 (95% CI 1.7-2.8) for current cigarette smokers, with a significant increasing trend in risk with increasing number of cigarettes among current smokers (OR = 3.4 for >= 35 cigarettes per day, P for trend < 0.0001). Risk increased in relation to duration of cigarette smoking up to 40 years of smoking (OR = 2.4). No trend in risk was observed for age at starting cigarette smoking, whereas risk decreased with increasing time since cigarette cessation, the OR being 0.98 after 20 years. This uniquely large pooled analysis confirms that current cigarette smoking is associated with a twofold increased risk of pancreatic cancer and that the risk increases with the number of cigarettes smoked and duration of smoking. Risk of pancreatic cancer reaches the level of never smokers similar to 20 years after quitting.

引用

页码：1880 / 1888

页数：9

共 33 条

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