State-of-the-Art Monitoring of Cytomegalovirus-Specific Cell-Mediated Immunity After Organ Transplant: A Primer for the Clinician

被引：122

作者：

Egli, Adrian ^{[1
]}

Humar, Atul ^{[1
]}

Kumar, Deepali ^{[1
]}

机构：

[1] Univ Alberta, Katz Ctr Hlth Res 6 030, Alberta Transplant Inst, Edmonton, AB T6G 2E1, Canada

来源：

CLINICAL INFECTIOUS DISEASES | 2012年 / 55卷 / 12期

关键词：

EXTENDED VALGANCICLOVIR PROPHYLAXIS; BONE-MARROW-TRANSPLANT; CD8; T-CELLS; CMV DISEASE; HIGH-RISK; LUNG TRANSPLANTATION; PREEMPTIVE THERAPY; RECIPIENTS; INFECTION; RESPONSES;

D O I：

10.1093/cid/cis818

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cytomegalovirus (CMV) is one of the most common infections after solid organ transplantation. Improved assays to predict viral replication and disease would help refine current preventive strategies. Monitoring of CMV-specific T-cell responses may help guide clinical decision making. Several techniques are now available to quantify CMV-specific T-cell responses, including flow cytometry, enzyme-linked immunosorbent spot assay, and enzyme-linked immunosorbent assay. Standardization and validation of these assays have the potential to significantly change the monitoring and treatment of CMV and further personalize CMV prevention strategies. In this review, we discuss the measurement of CMV-specific T-cell responses and their clinical impact on the management of CMV after organ transplantation.

引用

页码：1678 / 1689

页数：12

共 45 条

[1] Human Cytomegalovirus-Specific T-Cell Immune Reconstitution in Preemptively Treated Heart Transplant Recipients Identifies Subjects at Critical Risk for Infection [J].

Abate, Davide ;

Fiscon, Marta ;

Saldan, Alda ;

Cofano, Simona ;

Mengoli, Carlo ;

Sgarabotto, Dino ;

d'Agostino, Chiara ;

Barzon, Luisa ;

Cusinato, Riccardo ;

Toscano, Giuseppe ;

Feltrin, Giuseppe ;

Gambino, Antonio ;

Gerosa, Gino ;

Palu, Giorgio .

JOURNAL OF CLINICAL MICROBIOLOGY, 2012, 50 (06) :1974-1980

[2] Evaluation of Cytomegalovirus (CMV)-Specific T Cell Immune Reconstitution Revealed That Baseline Antiviral Immunity, Prophylaxis, or Preemptive Therapy but not Antithymocyte Globulin Treatment Contribute to CMV-Specific T Cell Reconstitution in Kidney Transplant Recipients [J].

Abate, Davide ;

Saldan, Alda ;

Fiscon, Marta ;

Cofano, Simona ;

Paciolla, Adriana ;

Furian, Lucrezia ;

Ekser, Burcin ;

Biasolo, Maria Angela ;

Cusinato, Riccardo ;

Mengoli, Carlo ;

Bonfante, Luciana ;

Rossi, Barbara ;

Rigotti, Paolo ;

Sgarabotto, Dino ;

Barzon, Luisa ;

Palu, Giorgio .

JOURNAL OF INFECTIOUS DISEASES, 2010, 202 (04) :585-594

[3] Long-Term Outcomes of CMV Disease Treatment with Valganciclovir Versus IV Ganciclovir in Solid Organ Transplant Recipients [J].

Asberg, A. ;

Humar, A. ;

Jardine, A. G. ;

Rollag, H. ;

Pescovitz, M. D. ;

Mouas, H. ;

Bignamini, A. ;

Toez, H. ;

Dittmer, I. ;

Montejo, M. ;

Hartmann, A. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2009, 9 (05) :1205-1213

[4] Protection from cytomegalovirus after transplantation is correlated with immediate early 1-specific CD8 T cells [J].

Bunde, T ;

Kirchner, A ;

Hoffmeister, B ;

Habedank, D ;

Hetzer, R ;

Cherepnev, G ;

Proesch, S ;

Reinke, P ;

Volk, HD ;

Lehmkuhl, H ;

Kern, F .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 201 (07) :1031-1036

[5] Monitoring Cytomegalovirus T-Cell Immunity in Small Bowel/Multivisceral Transplant Recipients [J].

Chiereghin, A. ;

Gabrielli, L. ;

Zanfi, C. ;

Petrisli, E. ;

Lauro, A. ;

Piccirilli, G. ;

Baccolini, F. ;

Dazzi, A. ;

Cescon, M. ;

Morelli, M. C. ;

Pinna, A. D. ;

Landini, M. P. ;

Lazzarotto, T. .

TRANSPLANTATION PROCEEDINGS, 2010, 42 (01) :69-73

[6] Evalvation and Significance of Cytomegalovirus-Specific Cellular Immune Response in Lung Transplant Recipients [J].

Costa, C. ;

Astegiano, S. ;

Terlizzi, M. E. ;

Sidoti, F. ;

Curtoni, A. ;

Solidoro, P. ;

Baldi, S. ;

Bergello, M. ;

Cavallo, R. .

TRANSPLANTATION PROCEEDINGS, 2011, 43 (04) :1159-1161

[7] Cytomegalovirus-specific T-cell responses and viral replication in kidney transplant recipients [J].

Egli, Adrian ;

Binet, Isabelle ;

Binggeli, Simone ;

Jaeger, Clemens ;

Dumoulin, Alexis ;

Schaub, Stefan ;

Steiger, Juerg ;

Sester, Urban ;

Sester, Martina ;

Hirsch, Hans H. .

JOURNAL OF TRANSLATIONAL MEDICINE, 2008, 6 (1)

[8] A prospective longitudinal analysis of cytomegalovirus (CMV)-specific CD4+and CD8+T cells in kidney allograft recipients at risk of CMV infection [J].

Eid, Albert J. ;

Brown, Robert A. ;

Arthurs, Supha K. ;

Lahr, Brian D. ;

Eckel-Passow, Jeanette E. ;

Larson, Timothy S. ;

Razonable, Raymund R. .

TRANSPLANT INTERNATIONAL, 2010, 23 (05) :506-513

[9] Serum antibody response to the gH/gL/pUL128-131 five-protein complex of human cytomegalovirus (HCMV) in primary and reactivated HCMV infections [J].

Genini, Emilia ;

Percivalle, Elena ;

Sarasini, Antonella ;

Revello, M. Grazia ;

Baldanti, Fausto ;

Gerna, Giuseppe .

JOURNAL OF CLINICAL VIROLOGY, 2011, 52 (02) :113-118

[10] Monitoring of human cytomegalovirus-specific CD4+ and CD8+ T-cell immunity in patients receiving solid organ transplantation [J].

Gerna, G. ;

Lilleri, D. ;

Fornara, C. ;

Comolli, G. ;

Lozza, L. ;

Campana, C. ;

Pellegrini, C. ;

Meloni, F. ;

Rampino, T. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2006, 6 (10) :2356-2364

← 1 2 3 4 5 →