Copper chelation as an antiangiogenic therapy

被引：39

作者：

Lowndes, SA ^{[1
]}

Harris, AL ^{[1
]}

机构：

[1] Churchill Hosp, Canc Res UK Med Oncol Unit, Oxford OX3 7LJ, England

来源：

ONCOLOGY RESEARCH | 2004年 / 14卷 / 11-12期

关键词：

copper; chelation; angiogenesis; antiangiogenic therapy;

D O I：

10.3727/0965040042707952

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Angiogenesis is now recognized as a crucial process in tumor development. Copper appears to act as an essential cofactor for several angiogenic growth factors, and both copper metabolism and ceruloplasmin expression are upregulated in many tumors. The role of copper chelators has been investigated in animal models with promising results. New therapies for Wilson's disease (a disease of copper accumulation) have enabled clinical trials of copper chelation to be undertaken. Here we discuss the evidence for a role of copper in angiogenesis and possible mechanisms of action of anticopper agents.

引用

页码：529 / 539

页数：11

共 92 条

[1] Host prostaglandin E2-EP3 signaling regulates tumor-associated angiogenesis and tumor growth [J].

Amano, H ;

Hayashi, J ;

Endo, H ;

Kitasato, H ;

Yamashina, S ;

Maruyama, T ;

Kobayashi, M ;

Satoh, K ;

Narita, M ;

Sugimoto, Y ;

Murata, T ;

Yoshimura, H ;

Narumiya, S ;

Majima, M .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (02) :221-232

[2]

APELGOT S, 1986, ANTICANCER RES, V6, P159

[3] Control of oncogenesis and cancer therapy resistance by the transcription factor NF-κB [J].

Baldwin, AS .

JOURNAL OF CLINICAL INVESTIGATION, 2001, 107 (03) :241-246

[4] Copper stimulates the synthesis and release of interleukin-8 in human endothelial cells: A possible early role in systemic inflammatory responses [J].

Bar-Or, D ;

Thomas, GW ;

Yukl, RL ;

Rael, LT ;

Shimonkevitz, RP ;

Curtis, CG ;

Winkler, JV .

SHOCK, 2003, 20 (02) :154-158

[5] Physiologic function of the Wilson disease gene product, ATP7B [J].

Bingham, MJ ;

Ong, TJ ;

Summer, KH ;

Middleton, RB ;

McArdle, HJ .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 1998, 67 (05) :982S-987S

[6]

Brem, 1999, Cancer Control, V6, P436

[7]

BREM SS, 1990, AM J PATHOL, V137, P1121

[8]

Brewer GJ, 2000, CLIN CANCER RES, V6, P1

[9] Treatment of Wilson disease with ammonium tetrathiomolybdate .2. Initial therapy in 33 neurologically affected patients and follow-up with zinc therapy [J].

Brewer, GJ ;

Johnson, V ;

Dick, RD ;

Kluin, KJ ;

Fink, JK ;

Brunberg, JA .

ARCHIVES OF NEUROLOGY, 1996, 53 (10) :1017-1025

[10] Copper control as an antiangiogenic anticancer therapy: Lessons from treating Wilson's disease [J].

Brewer, GJ .

EXPERIMENTAL BIOLOGY AND MEDICINE, 2001, 226 (07) :665-673

← 1 2 3 4 5 6 7 8 9 10 →