Vascular Endothelial Growth Factor as a Key Inducer of Angiogenesis in the Asthmatic Airways

被引:98
作者
Meyer, Norbert [1 ,2 ,3 ]
Akdis, Cezmi A. [1 ]
机构
[1] Univ Zurich, CK CARE, Swiss Inst Allergy & Asthma Res SIAF, Davos, Switzerland
[2] Spitalnetz Bern, Ziegler Hosp Dept Internal Med, Bern, Switzerland
[3] Spital Ziegler, CH-3001 Bern, Switzerland
基金
瑞士国家科学基金会;
关键词
Angiogenesis; Asthma; Vascular endothelial growth factor; VEGF; Interleukin-32; IL-32; Inflammatory pathways; Airways; Polymorphisms; Novel therapies; RESEARCH STRATEGIES; SAFETY EVALUATION; MURINE MODEL; VEGF; INFLAMMATION; NANOPARTICLES; EXPRESSION; HYPERRESPONSIVENESS; POLYMORPHISMS; NANOMATERIALS;
D O I
10.1007/s11882-012-0317-9
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Asthma is a chronic inflammatory disease of the airways characterized by structural airway changes, which are known as airway remodeling, including smooth muscle hypertrophy, goblet cell hyperplasia, subepithelial fibrosis, and angiogenesis. Vascular remodeling in asthmatic lungs results from increased angiogenesis, which is mainly mediated by vascular endothelial growth factor (VEGF). VEGF is a key regulator of blood vessel growth in the airways of asthma patients by promoting proliferation and differentiation of endothelial cells and inducing vascular leakage and permeability. In addition, VEGF induces allergic inflammation, enhances allergic sensitization, and has a role in Th2 type inflammatory responses. Specific inhibitors of VEGF and blockers of its receptors might be useful to control chronic airway inflammation and vascular remodeling, and might be a new therapeutic approach for chronic inflammatory airway disease like asthma.
引用
收藏
页码:1 / 9
页数:9
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