Evolution of myelodysplastic syndrome and acute myelogenous leukaemia in children with hepatitis-associated aplastic anaemia

被引：18

作者：

Ohara, A

Kojima, S

Okamura, J

Inada, H

Kigasawa, H

Hibi, S

Tsukimoto, I

机构：

[1] Toho Univ, Sch Med, Dept Pediat 1, Ota Ku, Tokyo 1438541, Japan

[2] Nagoya Univ, Sch Med, Dept Dev Pediat, Nagoya, Aichi 466, Japan

[3] Kyushu Canc Ctr, Dept Pediat, Fukuoka, Japan

[4] Kurume Univ, Sch Med, Dept Pediat, Kurume, Fukuoka 830, Japan

[5] Kanagawa Childrens Med Ctr, Dept Hematol, Yokohama, Kanagawa, Japan

[6] Kyoto Prefectural Univ, Sch Med, Dept Pediat, Kyoto 606, Japan

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2002年 / 116卷 / 01期

关键词：

aplastic anaemia; hepatitis; children; MDS;

D O I：

10.1046/j.1365-2141.2002.03229.x

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

In hepatitis-associated aplastic anaemia (HAA), an immune-mediated mechanism is solely responsible for the development of pancytopenia. We retrospectively analysed the clinical outcome of 61 children with HAA, diagnosed between 1988 and 1996. Of 61 patients, 41 did not receive bone marrow transplantation (BMT) and their survival rate at 7 years was 61.4 +/- 9.3%(SE). Five of these 41 patients developed myelodysplastic syndrome (MDS) or acute myelogenous leukaemia (AML) 7-57 months after the diagnosis of HAA. The incidence of MDS/AML in severe HAA patients who did not receive BMT (n = 30, 27.0 +/- 10-8%) appeared to be similar to that of severe idiopathic AA patients (n = 155, 14.7 +/- 3.7%) treated in the same period.

引用

页码：151 / 154

页数：4

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