Regulation of cell structure and function by actin-binding proteins: Villin's perspective

被引：129

作者：

Khurana, Seema ^{[1
]}

George, Sudeep P. ^{[1
]}

机构：

[1] Univ Tennessee, Hlth Sci Ctr, Dept Physiol, Memphis, TN 38163 USA

来源：

FEBS LETTERS | 2008年 / 582卷 / 14期

关键词：

villin; actin; actin-binding protein; epithelial cell; cell migration; apoptosis;

D O I：

10.1016/j.febslet.2008.02.040

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Villin is a tissue-specific actin modifying protein that is associated with actin filaments in the microvilli and terminal web of epithelial cells. It belongs to a large family of actin-binding proteins which includes actin-capping, -nucleating and/or - severing proteins such as gelsolin, severin, fragmin, adseverin/scinderin and actin crosslinking proteins such as dematin and supervillin. Studies done in epithelial cell lines and villin knock-out mice have demonstrated the function of villin in regulating actin dynamics, cell morphology, epithelial-to-mesenchymal transition, cell migration and cell survival. In addition, the ligand-binding properties of villin (F-actin, G-actin, calcium, phospholipids and phospholipase C-gamma(1)) are mechanistically important for the crosstalk between signaling pathways and actin reorganization in epithelial cells. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：2128 / 2139

页数：12

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