Gut microbiota composition correlates with diet and health in the elderly

被引：2327

作者：

Claesson, Marcus J. ^{[1
,2
]}

Jeffery, Ian B. ^{[1
,2
]}

Conde, Susana ^{[3
]}

Power, Susan E. ^{[1
]}

O'Connor, Eibhlis M. ^{[1
,2
]}

Cusack, Siobhan ^{[1
]}

Harris, Hugh M. B. ^{[1
]}

Coakley, Mairead ^{[4
]}

Lakshminarayanan, Bhuvaneswari ^{[4
]}

O'Sullivan, Orla ^{[4
]}

Fitzgerald, Gerald F. ^{[1
,2
]}

Deane, Jennifer ^{[1
]}

O'Connor, Michael ^{[5
,6
]}

Harnedy, Norma ^{[5
,6
]}

O'Connor, Kieran ^{[6
,7
,8
]}

O'Mahony, Denis ^{[5
,6
,8
]}

van Sinderen, Douwe ^{[1
,2
]}

Wallace, Martina ^{[9
]}

Brennan, Lorraine ^{[9
]}

Stanton, Catherine ^{[2
,4
]}

Marchesi, Julian R. ^{[10
]}

Fitzgerald, Anthony P. ^{[3
,11
]}

Shanahan, Fergus ^{[2
,12
]}

Hill, Colin ^{[1
,2
]}

Ross, R. Paul ^{[2
,4
]}

O'Toole, Paul W. ^{[1
,2
]}

机构：

[1] Univ Coll Cork, Dept Microbiol, Cork, Ireland

[2] Univ Coll Cork, Alimentary Pharmabiot Ctr, Cork, Ireland

[3] Univ Coll Cork, Dept Stat, Cork, Ireland

[4] TEAGASC, Moorepk Food Res Ctr, Fermoy, Cork, Ireland

[5] Cork Univ Hosp, Cork, Ireland

[6] St Finbarrs Hosp, Cork, Ireland

[7] Mercy Univ Hosp, Cork, Ireland

[8] Victoria Univ Hosp, South Infirm, Cork, Ireland

[9] Univ Coll Dublin, Inst Food & Hlth, Dublin, Ireland

[10] Cardiff Univ, Sch Biosci, Cardiff CF10 3AT, S Glam, Wales

[11] Univ Coll Cork, Dept Epidemiol & Publ Hlth, Cork, Ireland

[12] Univ Coll Cork, Dept Med, Cork, Ireland

来源：

NATURE | 2012年 / 488卷 / 7410期

基金：

爱尔兰科学基金会;

关键词：

PHYLOGENETIC MICROARRAY; FECAL MICROBIOTA; SEQUENCES; UNIFRAC; INDEX; AGE;

D O I：

10.1038/nature11319

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Alterations in intestinal microbiota composition are associated with several chronic conditions, including obesity and inflammatory diseases. The microbiota of older people displays greater inter-individual variation than that of younger adults. Here we show that the faecal microbiota composition from 178 elderly subjects formed groups, correlating with residence location in the community, day-hospital, rehabilitation or in long-term residential care. However, clustering of subjects by diet separated them by the same residence location and microbiota groupings. The separation of microbiota composition significantly correlated with measures of frailty, co-morbidity, nutritional status, markers of inflammation and with metabolites in faecal water. The individual microbiota of people in long-stay care was significantly less diverse than that of community dwellers. Loss of community-associated microbiota correlated with increased frailty. Collectively, the data support a relationship between diet, microbiota and health status, and indicate a role for diet-driven microbiota alterations in varying rates of health decline upon ageing.

引用

页码：178 / +

页数：8

共 55 条

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