Treatment of sperm with subnormal host scores with chymotrypsin/viable pregnancy after IUI

被引：10

作者：

Check, ML

Kiefer, D

Check, JH

Hourani, W

Long, R

机构：

[1] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Camden, NJ 08103 USA

[2] Cooper Hosp Univ Med Ctr, Dept Obstet Gynecol, Div Reprod Endocrinol Inferil, Camden, NJ 08103 USA

来源：

ARCHIVES OF ANDROLOGY | 2002年 / 48卷 / 02期

关键词：

chymotrypsin; hypoosmotic swelling test; intrauterine insemination;

D O I：

10.1080/014850102317267472

中图分类号：

R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

摘要：

Men with low hypoosmotic swelling test (HOST) scores (<50%) rarely achieve a pregnancy with intercourse or conventional intrauterine insemination (IUI) or even lVF. The defect seems to be related to a toxic factor attached to the sperm that can be transferred to the zona pellucida, which ultimately interferes with implantation. A small case series showed optimistic pregnancy outcome with treatment of the sperm with low HOST scores with chymotrypsin. However, the live pregnancy rate in 90 subsequent IUI cycles in men whose low HOST scores were improved by chymotrypsin was only 3.3%. lVF with ICSI remains the only highly effective treatment of this disorder.

引用

收藏

页码：155 / 158

页数：4

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