Consciousness and Anesthesia

被引:870
作者
Alkire, Michael T. [2 ,3 ]
Hudetz, Anthony G. [4 ]
Tononi, Giulio [1 ]
机构
[1] Univ Wisconsin, Dept Psychiat, Madison, WI 53719 USA
[2] Univ Calif Irvine, Dept Anesthesiol, Irvine, CA 92868 USA
[3] Univ Calif Irvine, Ctr Neurobiol Learning & Memory, Irvine, CA 92868 USA
[4] Med Coll Wisconsin, Dept Anesthesiol, Milwaukee, WI 53226 USA
关键词
D O I
10.1126/science.1149213
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
When we are anesthetized, we expect consciousness to vanish. But does it always? Although anesthesia undoubtedly induces unresponsiveness and amnesia, the extent to which it causes unconsciousness is harder to establish. For instance, certain anesthetics act on areas of the brain's cortex near the midline and abolish behavioral responsiveness, but not necessarily consciousness. Unconsciousness is likely to ensue when a complex of brain regions in the posterior parietal area is inactivated. Consciousness vanishes when anesthetics produce functional disconnection in this posterior complex, interrupting cortical communication and causing a loss of integration; or when they lead to bistable, stereotypic responses, causing a loss of information capacity. Thus, anesthetics seem to cause unconsciousness when they block the brain's ability to integrate information.
引用
收藏
页码:876 / 880
页数:5
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