Identification of plasticizers in medical products by a combined direct thermodesorption-cooled injection system and gas chromatography-mass spectrometry

被引:58
作者
Wahl, HG [1 ]
Hoffmann, A
Häring, HU
Liebich, HM
机构
[1] Univ Tubingen, Med Klin, Abt 4, Zent Lab, D-72076 Tubingen, Germany
[2] Gerstel GmbH, D-45473 Mulheim, Germany
关键词
thermodesorption; cooled injection system; injection methods; plasticizers; diethylhexyl phthalate; phthalates; poly(vinyl chloride);
D O I
10.1016/S0021-9673(99)00138-7
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The combination of a new thermodesorption module with a cooled injection system now provides a powerful system for direct analysis of volatile trace compounds in gaseous, liquid and solid samples by gas chromatography-mass spectrometry (GC-MS). As a cooled injection system is used for the cryofocusing of the desorbed volatiles the GC-MS system still can be used for the regular analysis of liquid samples. Although plasticizers usually are analyzed by CC-MS after solvent extraction, contaminated solvents and glassware are very well known problems. Analysis of plasticizers in plastic materials by direct thermodesorption instead saves time and avoids cross contaminations. Many medical products are made of plasticized polyvinyl chloride. Extraction of the common plasticizer di(2-ethylhexyl) phthalate (DEHP) into blood will occur, and harmful effects of DEHP in the human body have been suggested. We therefore analyzed 21 different plastic devices which are used for various invasive techniques in medicine by direct thermodesorption CC-MS. In some of the plastics up to 30 different components were identified. By far the most common plasticizer found was DEHP, followed by diethyl and dibutyl phthalates. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
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页码:1 / 7
页数:7
相关论文
共 20 条
[1]  
AMESON DW, 1995, J APPL TOXICOL, V15, P1
[2]   A MULTIDISCIPLINARY APPROACH TO TOXICOLOGICAL SCREENING .1. SYSTEMIC TOXICITY [J].
BERMAN, E ;
SCHLICHT, M ;
MOSER, VC ;
MACPHAIL, RC .
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH, 1995, 45 (02) :127-143
[3]   BIOCOMPATIBILITY OF BLOOD TUBINGS [J].
BRANGER, B ;
GARREAU, M ;
BAUDIN, G ;
GRIS, JC .
INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, 1990, 13 (10) :697-703
[4]  
CIMINI AM, 1994, CELL MOL BIOL, V40, P1063
[5]   EFFECTS OF CHRONIC PHTHALATE EXPOSURE ON THE KIDNEY [J].
CROCKER, JFS ;
SAFE, SH ;
ACOTT, P .
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH, 1988, 23 (04) :433-444
[6]   METABOLISM OF 2-ETHYLHEXANOL ADMINISTERED ORALLY AND DERMALLY TO THE FEMALE FISCHER-344 RAT [J].
DEISINGER, PJ ;
BOATMAN, RJ ;
GUEST, D .
XENOBIOTICA, 1994, 24 (05) :429-440
[7]   DETERMINATION OF 4 METABOLITES OF THE PLASTICIZER DI(2-ETHYLHEXYL)PHTHALATE IN HUMAN URINE SAMPLES [J].
DIRVEN, HAAM ;
VANDENBROEK, PHH ;
JONGENEELEN, FJ .
INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH, 1993, 64 (08) :555-560
[8]  
FLAMINIO LM, 1988, INT J ARTIF ORGANS, V11, P435
[9]  
FLAMINIO LM, 1988, INT J ARTIF ORGANS, V11, P428
[10]   GAS CHROMATOGRAPHIC-MASS SPECTROMETRIC STUDY OF VOLATILE ORGANIC METABOLITES IN URINES OF PATIENTS WITH DIABETES-MELLITUS [J].
LIEBICH, HM ;
ALBABBILI, O .
JOURNAL OF CHROMATOGRAPHY, 1975, 112 (OCT29) :539-550