The coactivator LXXLL nuclear receptor recognition motif

被引：205

作者：

Savkur, RS ^{[1
]}

Burris, TP ^{[1
]}

机构：

[1] Eli Lilly & Co, Lilly Corp Ctr, Lilly Res Labs, Indianapolis, IN 46285 USA

来源：

JOURNAL OF PEPTIDE RESEARCH | 2004年 / 63卷 / 03期

关键词：

coactivator; corepressor; nuclear receptor; steroid receptor; transcription;

D O I：

10.1111/j.1399-3011.2004.00126.x

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Nuclear receptors require coactivator binding in order to activate transcription of their cognate target genes. Ligands regulate nuclear receptor (NR)-mediated recruitment of coactivators by binding to the ligand-binding domain of the receptor and inducing a conformational change allowing for recognition of a specific motif contained within the coactivator protein. This motif is known as the NR box or LXXLL (where L is leucine and X is any amino acid) domain. Here, we review the discovery of the domain as well as its characterization.

引用

页码：207 / 212

页数：6

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