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Experience From Experimental Cell Transplantation Therapy of Myocardial Infarction: What Have We Learned?

被引：10
作者：
Dai, Wangde
Kay, Gregory L.
Jyrala, Aarne J.
Kloner, Robert A.
机构：
[1] Univ So Calif, Good Samaritan Hosp, Inst Heart, Los Angeles, CA USA
[2] Univ So Calif, Keck Sch Med, Div Cardiovasc Med, Los Angeles, CA 90033 USA
来源：
CELL TRANSPLANTATION | 2013年 / 22卷 / 03期
关键词：
Cell transplantation therapy; Fetal/neonatal cardiomyocyte; Mesenchymal stem cell (MSC); Embryonic stem cell-derived cardiomyocyte (hESC-CM); Myocardial infarction; NEONATAL RAT CARDIOMYOCYTES; CORONARY-ARTERY OCCLUSION; STEM-CELLS; HEART-FAILURE; SURVIVAL; TERM;
D O I：
10.3727/096368911X627570
中图分类号：
Q813 [细胞工程];
学科分类号：
100113 [医学细胞生物学];
摘要：
During the past 15 years, our research group has transplanted fetal/neonatal cardiomyocytes, mesenchymal stem cells, and embryonic stem cell-derived cardiomyocytes into infarcted myocardium in a rat myocardial infarction model. Our experimental data demonstrated that cell transplantation therapy provides a potential approach for the treatment of injured myocardium after myocardial infarction based on the reported positive effects upon histological appearance and left ventricular function. However, the underlying mechanisms of the benefits from cell transplantation therapy remain unclear and may involve replacement of scar tissue by transplanted cells, induced neoangiogenesis and paracrine effects of factors released by the transplanted cells. In this review, we summarize our experiences from experimental cell transplantation therapy in a rat myocardial infarction model and discuss the controversies and questions that need to be addressed in future studies.
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收藏
页码：563 / 568
页数：6
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