Renal resistive index early detects chronic tubulointerstitial nephropathy in normo- and hypertensive patients

Background. We studied whether the measurement of intrarenal vascular resistance by Doppler ultrasonography, capable of investigating renal interstitial compartment, allows the early detection of chronic tubulointerstitial nephropathy (TIN). Methods:30 normotensive and 28 hypertensive (I-II OMS) patients with a clinical history suggestive of chronic TIN and normal renal function were enrolled. 40 healthy volunteers served as controls. Patients were considered TIN-negative or TIN-positive after investigating tubular function by urine concentrating and acidification tests. Renal sonographic parameters and renal resistive index (RRI) were obtained by duplex scanner. Glomerular filtration rate/effective renal plasmatic flow ratio was investigated by sequential renal scintigraphy in TIN-negative and TIN-positive patients; Tc-99m-DMSA scintigraphy was also performed in TIN-positive patients. Results: RRI values of TIN-positive normotensive and hypertensive patients were significantly higher (p<0.01 for both) than those of TIN-negative patients and of controls. RRI values resulted to be linearly related to uricemia (r=0.88, p<0.0001) only in normotensive patients. RRI values also resulted to be linearly related to filtration ratio values (r=0.60, p<0.0001). Tc-99m-DMSA scintigraphy confirmed interstitial renal damage (grade 1 and 2). Conclusion: RRI measurement allows the early identification of both normotensive and hypertensive patients with chronic TIN and signs of tubular dysfunction, when renal function is still preserved. Copyright (C) 2006 S. Karger AG, Basel.