Antiinflammatory and immunomodulatory properties of statins

被引:63
作者
Shovman, O
Levy, Y
Gilburd, B
Shoenfeld, Y [1 ]
机构
[1] Chaim Sheba Med Ctr, Dept Med B, IL-52621 Tel Hashomer, Israel
[2] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel
关键词
atherosclerosis; inflammation; immune system; statins; monocytes; endothelial cells; lymphocytes; smooth muscle cells;
D O I
10.1385/IR:25:3:271
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase or statins constitute the most powerful class of lipid lowering drugs. widely used in medical practice. During the past several years additional actions of statins unrelated to cholesterol reduction have been identified which includes antiinflammatory and immunomodulatory properties. Since atherosclerosis is a form of inflammation and the immune system play an important role in its pathogenesis, pleiotropic effect of statins may provide complementary explanation to their clinical benefit. This article reviews the data regarding the antiinflammatory and immunomodulatory properties of the statins that are available in the treatment of atherosclerosis and possibly may be applicable in other inflammatory diseases or conditions with the involvement of the immune system.
引用
收藏
页码:271 / 285
页数:15
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