Low Brain Iron Content in Idiopathic Restless Legs Syndrome Patients Detected by Phase Imaging

被引：115

作者：

Rizzo, Giovanni ^{[1
,2
,3
]}

Manners, David ^{[1
]}

Testa, Claudia ^{[1
]}

Tonon, Caterina ^{[1
]}

Vetrugno, Roberto ^{[4
]}

Marconi, Sara ^{[2
,3
]}

Plazzi, Giuseppe ^{[2
,3
]}

Pizza, Fabio ^{[2
,3
]}

Provini, Federica ^{[2
,3
]}

Malucelli, Emil ^{[5
]}

Gramegna, Laura Ludovica ^{[1
]}

Lodi, Raffaele ^{[1
]}

机构：

[1] Univ Bologna, Dept Biomed & NeuroMotor Sci DiBiNeM, Funct MR Unit, I-40138 Bologna, Italy

[2] Univ Bologna, Dept Biomed & NeuroMotor Sci DiBiNeM, Neurol Unit, I-40138 Bologna, Italy

[3] IRCCS Ist Sci Neurol Bologna, Bologna, Italy

[4] Profess Consultant Neurol, Bologna, Italy

[5] Univ Bologna, Dept Pharm & Biotechnol, I-40138 Bologna, Italy

来源：

MOVEMENT DISORDERS | 2013年 / 28卷 / 13期

关键词：

MRI; RLS; iron; phase imaging; SUBSTANTIA-NIGRA; T2; RELAXOMETRY; EARLY-ONSET; DEFICIENCY; METABOLISM; FERRITIN;

D O I：

10.1002/mds.25576

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

BackgroundThe objective of this study was to use phase imaging to evaluate brain iron content in patients with idiopathic restless legs syndrome (RLS). MethodsFifteen RLS patients and 15 healthy controls were studied using gradient-echo imaging. Phase analysis was performed on localized brain regions of interest selected on phase maps, sensitive to paramagnetic tissue. Differences between the 2 subject groups were evaluated using ANCOVA including age as a covariate. ResultsSignificantly higher phase values were present in the RLS patients compared with healthy controls at the level of the substantia nigra, thalamus, putamen, and pallidum, indicating reduced iron content in several regions of the brain of the patients. ConclusionsWe have used MRI phase analysis to study brain iron content in idiopathic RLS in vivo for the first time. Our results support the hypothesis of reduced brain iron content in RLS patients, which may have an important role in the pathophysiology of the disorder. (c) 2013 International Parkinson and Movement Disorder Society

引用

页码：1886 / 1890

页数：5

共 28 条

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