Epoxide opening with amino acids: improved synthesis of hydroxyethylamine dipeptide isosteres

被引：17

作者：

Babic, A

Sova, M

Gobec, S

Pecar, S

机构：

[1] Univ Ljubljana, Fac Pharm, Ljubljana 1000, Slovenia

[2] Jozef Stefan Inst, Ljubljana 1000, Slovenia

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 11期

关键词：

proteases; hydroxyethylamine dipeptide isosteres; aminolysis; calcium trifluoromethanesulfonate; epoxides; peptidomimetics;

D O I：

10.1016/j.tetlet.2006.01.058

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The amino acid opening of epoxides, catalyzed by calcium trifluoromethanesulfonate with short reaction times is described. The method can be used in a straightforward route for the preparation of hydroxyethylamine dipeptide isosteres. (c) 2006 Elsevier Ltd. All rights reserved.

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页码：1733 / 1735

页数：3

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