Combinatorial signalling by Xwnt-11 and Xnr3 in the organizer epithelium

被引：56

作者：

Glinka, A

Delius, H

Blumenstock, C

Niehrs, C

机构：

[1] DEUTSCH KREBSFORSCHUNGSZENTRUM,DIV MOL EMBRYOL,D-69120 HEIDELBERG,GERMANY

[2] DEUTSCH KREBSFORSCHUNGSZENTRUM,DIV APPL TUMOR VIROL,D-69120 HEIDELBERG,GERMANY

来源：

MECHANISMS OF DEVELOPMENT | 1996年 / 60卷 / 02期

关键词：

organizer; Xenopus; Xnr3; Xwnt-11;

D O I：

10.1016/S0925-4773(96)00624-7

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The epithelium of the Spemann organizer plays an important role in embryonic axis formation and transplantation experiments have shown that epithelial organizer cells have potent axis-inducing potential. Known axis-inducing molecules like noggin and chordin are not expressed in the epithelium and cannot account for its inductive properties. Xwnt-11 is expressed in the epithelium but has only poor dorsalizing activity. In an expression screen for genes that are able to functionally cooperate with Xwnt-11 we have identified a cDNA encoding Xenopus nodal-related 3 (Xnr3), a member of the TGF-beta family, coexpressed with Xwnt-11 in the organizer epithelium. Xwnt-11 and Xnr3 act highly cooperatively in inducing secondary embryonic axes and dorsalizing ventral mesoderm. Xwnt-11/Xnr3 interfere with BMP signalling without themselves inducing chordin or noggin. The results indicate that induction by the organizer epithelium may result from the combinatorial action of instructive Xnr3 and permissive Xwnt-11 signalling.

引用

页码：221 / 231

页数：11

共 53 条

[1] EXPRESSION OF A DOMINANT NEGATIVE MUTANT OF THE FGF RECEPTOR DISRUPTS MESODERM FORMATION IN XENOPUS EMBRYOS [J].