Current update on established and novel biomarkers in salivary gland carcinoma pathology and the molecular pathways involved

被引：66

作者：

Stenner, Markus ^{[1
]}

Klussmann, J. Peter ^{[1
]}

机构：

[1] Univ Hosp Cologne, Dept Otorhinolaryngol Head & Neck Surg, Sch Med, D-50937 Cologne, Germany

来源：

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY | 2009年 / 266卷 / 03期

关键词：

Salivary gland carcinoma; Molecular pathology; Immunohistochemistry; Prognostic markers; ADENOID CYSTIC CARCINOMA; EPIDERMAL-GROWTH-FACTOR; PANCREATIC-CANCER; FACTOR RECEPTOR; CELL-PROLIFERATION; DUCT CARCINOMA; PROGNOSTIC-SIGNIFICANCE; PROGESTERONE-RECEPTORS; MUCOEPIDERMOID CARCINOMAS; MONOCLONAL-ANTIBODY;

D O I：

10.1007/s00405-008-0882-7

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 [耳鼻咽喉科学];

摘要：

This review aims to take stock of the new information that has accumulated over the past decade on the molecular pathology of salivary gland cancer. Emphasis will be placed on established and novel immunohistochemical markers, the pathways involved, and on findings of prognostic importance as well as new therapeutic concepts. Whenever reasonable, analogies to tumors of better explored, histologically related glandular organs such as pancreas and breast are established.

引用

页码：333 / 341

页数：9

共 71 条

[1]

Phase II study of lapatinib in recurrent or metastatic epidermal growth factor receptor and/or erbB2 expressing adenoid cystic carcinoma and non-adenoid cystic carcinoma malignant tumors of the salivary glands [J].

Agulnik, Mark ;

Cohen, Ezra W. E. ;

Cohen, Roger B. ;

Chen, Eric X. ;

Vokes, Everett E. ;

Hotte, Sebastien J. ;

Winquist, Eric ;

Laurie, Scott ;

Hayes, D. Neil ;

Dancey, Janet E. ;

Brown, Shirley ;

Pond, Gregory R. ;

Lorimer, Ian ;

Daneshmand, Manijeh ;

Ho, James ;

Tsao, Ming-Sound ;

Siu, Lillian L. .

JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (25) :3978-3984

[2]

Araki Y, 2003, CANCER RES, V63, P728

[3]

Barnes L., 2005, World Health Organization Classification of tumors. Pathology and Genetics of Head and Neck Tumors, P209

[4]

TUNEL - an efficient prognosis predictor of salivary malignancies [J].

Ben-Izhak, O. ;

Laster, Z. ;

Araidy, S. ;

Nagler, R. M. .

BRITISH JOURNAL OF CANCER, 2007, 96 (07) :1101-1106

[5]

Gene therapy developments for pancreatic cancer [J].

Bhattacharrya, M ;

Lemoine, NR .

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY, 2006, 20 (02) :285-298

[6]

Bcl-2 expression in pancreas development and pancreatic cancer progression [J].

Campani, D ;

Esposito, I ;

Boggi, U ;

Cecchetti, D ;

Menicagli, M ;

De Negri, F ;

Colizzi, L ;

Del Chiaro, M ;

Mosca, F ;

Fornaciari, G ;

Bevilacqua, G .

JOURNAL OF PATHOLOGY, 2001, 194 (04) :444-450

[7]

Advances in salivary gland pathology [J].

Cheuk, W. ;

Chan, J. K. C. .

HISTOPATHOLOGY, 2007, 51 (01) :1-20

[8]

Cho KJ, 1999, HEAD NECK-J SCI SPEC, V21, P414

[9]

Coppola D, 2000, Cancer Control, V7, P421

[10]

Dergham S T, 1998, J Hepatobiliary Pancreat Surg, V5, P269, DOI 10.1007/s005340050045

← 1 2 3 4 5 6 7 8 →