Body mass index, lifestyles, physical performance and cognitive decline: The "Treviso Longeva (Trelong)" study

被引:67
作者
Gallucci, M. [1 ,9 ]
Mazzuco, S. [2 ]
Ongaro, F. [2 ]
Di Giorgi, E. [3 ]
Mecocci, P. [4 ]
Cesari, M. [5 ]
Albani, D. [6 ]
Forloni, G. L. [6 ]
Durante, E. [7 ]
Gajo, G. B. [7 ]
Zanardo, A. [8 ,9 ]
Siculi, M. [8 ]
Caberlotto, L. [8 ]
Regini, C. [9 ]
机构
[1] Gen Hosp Treviso, Cognit Impairment Ctr, I-31100 Treviso, Italy
[2] Univ Padua, Dept Stat, I-35121 Padua, Italy
[3] Territorial Hlth Serv Treviso, I-31100 Treviso, Italy
[4] Univ Hosp, Inst Gerontol & Geriatr, I-06156 Perugia, Italy
[5] Univ Toulouse, Inst Vieillissement, F-31000 Toulouse, France
[6] Mario Negri Inst Pharmacol Res, Dept Neurosci, I-20156 Milan, Italy
[7] Gen Hosp Treviso, Dept Transfus Med, I-31100 Treviso, Italy
[8] Gen Hosp Treviso, Dept Clin Pathol, I-31100 Treviso, Italy
[9] Interdisciplinary Geriatr Res Fdn, FORGEI, I-31100 Treviso, Italy
关键词
Cognitive decline; body mass index (BMI); physical performance; lifestyles; CHARLSON COMORBIDITY INDEX; VASCULAR RISK-FACTORS; ALZHEIMERS-DISEASE; WEIGHT CHANGE; INCIDENT DEMENTIA; GRIP STRENGTH; OLDER-ADULTS; FOLLOW-UP; FUNCTIONAL STATUS; TERM MORTALITY;
D O I
10.1007/s12603-012-0397-1
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
030301 [社会学]; 100201 [内科学];
摘要
The relative contributions of risk factors, as body mass index (BMI), depression, chronic diseases, smoking, and lifestyles (as physical and performance activity, social contacts and reading habit) to cognitive decline in the elderly are unclear. We explored these variables in relation to 7-year cognitive decline in long-lived Italian elderly. Secondary data analysis of a longitudinal study of a representative, age-stratified, population sample. The TREVISO LONGEVA (TRELONG) Study, in Treviso, Italy. 120 men and 189 women, age 77 years and older (mean age 80.2 +/- 6.9 years) survivors after seven years of follow up. Cognitive decline measured as difference between Mini-Mental State Examination (MMSE) score in 2003 and in 2010; Body mass index (BMI), handgrip, Short Physical Performance Battery (SPPB) score, social contacts, reading habit, sight, hearing, schooling, mediterranean diet and multiple clinical and survey data recorded at baseline in 2003. In separate univariate analyses, age, SPPB score < 5, depressive symptoms (GDS) and more comorbidities (CCI) were associated with greater cognitive decline. Otherwise higher BMI, higher handgrip, reading habit, non-deteriorated sight and hearing, and schooling were protective. In a final multivariate model, age and higher BMI were associated with greater cognitive decline while reading habits was protective. SPPB score < 5 tends, though weakly, to be associated with greater cognitive decline. These associations remained with multivariate adjustment for gender, schooling, Charlson co-morbidity index (CCI) and baseline MMSE. Age and higher baseline BMI, independent of gender, and other confounding factors, are risk factors for cognitive decline. Reading habit plays a protective role seven years later among northern Italian adults aged 70 years or older. Low physical performance tends, though weakly, to be associated with greater cognitive decline.
引用
收藏
页码:378 / 384
页数:7
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