Penicillin tolerance and modification of lipoteichoic acid associated with expression of vancomycin resistance in VanB-type Enterococcus faecium D366

被引：16

作者：

Gutmann, L ^{[1
]}

AlObeid, S ^{[1
]}

BillotKlein, D ^{[1
]}

Ebnet, E ^{[1
]}

Fischer, W ^{[1
]}

机构：

[1] UNIV ERLANGEN NURNBERG,INST BIOCHEM,D-91054 ERLANGEN,GERMANY

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1996年 / 40卷 / 01期

关键词：

D O I：

10.1128/AAC.40.1.257

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Induction of vancomycin resistance in Enterococcusfaecium D366, which exhibits a VanB-type resistance, as well as its constitutive expression in MT9, a derivative of D366, was associated with penicillin tolerance as shown by decreased lysis and killing of the cells. This phenomenon was linked neither to decreased expression of the different autolysins nor to their decreased lytic activity on the different cell walls. The only change observed was that almost twice the normal amount of D-alanine was attached to the lipoteichoic acid.

引用

页码：257 / 259

页数：3

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