Abscopal but desirable The contribution of immune responses to the efficacy of radiotherapy

被引：48

作者：

Kroemer, Guido ^{[1
,2
,3
,4
,5
]}

Zitvogel, Laurence ^{[2
,6
,7
,8
]}

机构：

[1] INSERM, U848L, Villejuif, France

[2] Inst Gustave Roussy, Villejuif, France

[3] Ctr Rech Cordeliers, Paris, France

[4] Hop Europeen Georges Pompidou, AP HP, Paris, France

[5] Univ Paris 05, Fac Med, Paris, France

[6] Inst Gustave Roussy, INSERM, U1015, F-94805 Villejuif, France

[7] Inst Gustave Roussy, Ctr Clin Invest CBT507, Villejuif, France

[8] Univ Paris Sud, Villejuif, France

来源：

ONCOIMMUNOLOGY | 2012年 / 1卷 / 04期

关键词：

CELL-CARCINOMA; REGRESSION; IRRADIATION; LYMPHOMA; PATIENT;

D O I：

10.4161/onci.20074

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Radiotherapy applies ionizing irradiation to selected areas of the body with the scope of destroying cancer cells, either as part of curative therapies to remove a primary malignant tumor and to prevent tumor recurrence after surgery, or as part of palliative measures to avoid local advancement of bone and brain metastases. Intriguingly, radiotherapy does not only have local effects but may lead to the delayed regression of distant non-irradiated lesions. Most likely, these "abscopal" effects are mediated by the immune system.

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页数：2

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