The Application of Cerebrospinal Fluid Biomarkers in Early Diagnosis of Alzheimer Disease

被引：49

作者：

Blennow, Kaj ^{[1
]}

Zetterberg, Henrik ^{[1
]}

机构：

[1] Univ Gothenburg, Sahlgrenska Acad, Clin Neurochem Lab, Inst Neurosci & Physiol, SE-43180 Molndal, Sweden

来源：

MEDICAL CLINICS OF NORTH AMERICA | 2013年 / 97卷 / 03期

关键词：

Alzheimer disease; Cerebrospinal fluid; Biomarkers; Early diagnosis; Amyloid of A beta; Tau protein; MILD COGNITIVE IMPAIRMENT; BETA-AMYLOID; 1-42; CSF BIOMARKERS; TAU-PROTEIN; MARKERS; ONSET; BETA-AMYLOID((1-42)); ASSOCIATION; PREDICTORS; DEMENTIA;

D O I：

10.1016/j.mcna.2012.12.012

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This article gives an updated account of the clinical application of cerebrospinal fluid (CSF) biomarkers for Alzheimer disease (AD). The clinically most relevant biomarkers, total tau, phospho-tau and A beta 42 are discussed, and how they may be used, together with other diagnostic investigations, to make a predementia diagnosis of AD. Recent findings in sporadic and genetic preclinical AD are also discussed and, more specifically, what the biomarkers have taught us on the sequence of events in the pathogenic process underlying AD.

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页码：369 / +

页数：9

相关论文

共 42 条

[1] Cerebrospinal fluid tau and Aβ42 as predictors of development of Alzheimer's disease in patients with mild cognitive impairment [J].

Andreasen, N ;

Minthon, L ;

Vanmechelen, E ;

Vanderstichele, H ;

Davidsson, P ;

Winblad, B ;

Blennow, K .

NEUROSCIENCE LETTERS, 1999, 273 (01) :5-8

[2] Cerebrospinal fluid β-amyloid(1-42) in Alzheimer disease -: Differences between early- and late-onset Alzheimer disease and stability during the course of disease [J].

Andreasen, N ;

Hesse, C ;

Davidsson, P ;

Minthon, L ;

Wallin, A ;

Winblad, B ;

Vanderstichele, H ;

Vanmechelen, E ;

Blennow, K .

ARCHIVES OF NEUROLOGY, 1999, 56 (06) :673-680

[3] Evaluation of CSF-tau and CSF-Aβ42 as diagnostic markers for Alzheimer disease in clinical practice [J].

Andreasen, N ;

Minthon, L ;

Davidsson, P ;

Vanmechelen, E ;

Vanderstichele, H ;

Winblad, B ;

Blennow, K .

ARCHIVES OF NEUROLOGY, 2001, 58 (03) :373-379

[4] Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease [J].

Bateman, Randall J. ;

Xiong, Chengjie ;

Benzinger, Tammie L. S. ;

Fagan, Anne M. ;

Goate, Alison ;

Fox, Nick C. ;

Marcus, Daniel S. ;

Cairns, Nigel J. ;

Xie, Xianyun ;

Blazey, Tyler M. ;

Holtzman, David M. ;

Santacruz, Anna ;

Buckles, Virginia ;

Oliver, Angela ;

Moulder, Krista ;

Aisen, Paul S. ;

Ghetti, Bernardino ;

Klunk, William E. ;

McDade, Eric ;

Martins, Ralph N. ;

Masters, Colin L. ;

Mayeux, Richard ;

Ringman, John M. ;

Rossor, Martin N. ;

Schofield, Peter R. ;

Sperling, Reisa A. ;

Salloway, Stephen ;

Morris, John C. .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 367 (09) :795-804

[5] CSF markers for incipient Alzheimer's disease [J].

Blennow, K ;

Hampel, H .

LANCET NEUROLOGY, 2003, 2 (10) :605-613

[6] tau protein in cerebrospinal fluid - A biochemical marker for axonal degeneration in Alzheimer disease? [J].

Blennow, K ;

Wallin, A ;

Agren, H ;

Spenger, C ;

Siegfried, J ;

Vanmechelen, E .

MOLECULAR AND CHEMICAL NEUROPATHOLOGY, 1995, 26 (03) :231-245

[7] Cerebrospinal Fluid Protein Biomarkers for Alzheimer's Disease [J].

Blennow K. .

NeuroRX, 2004, 1 (2) :213-225

[8] Biomarkers in Alzheimer's disease drug development [J].

Blennow, Kaj .

NATURE MEDICINE, 2010, 16 (11) :1218-1222

[9] Cerebrospinal fluid and plasma biomarkers in Alzheimer disease [J].

Blennow, Kaj ;

Hampel, Harald ;

Weiner, Michael ;

Zetterberg, Henrik .

NATURE REVIEWS NEUROLOGY, 2010, 6 (03) :131-144

[10] Cerebrospinal Fluid Levels of β-Amyloid 1-42, but Not of Tau, Are Fully Changed Already 5 to 10 Years Before the Onset of Alzheimer Dementia [J].

Buchhave, Peder ;

Minthon, Lennart ;

Zetterberg, Henrik ;

Wallin, Asa K. ;

Blennow, Kaj ;

Hansson, Oskar .

ARCHIVES OF GENERAL PSYCHIATRY, 2012, 69 (01) :98-106

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