The iron efflux protein ferroportin regulates the intracellular growth of Salmonella enterica

被引：129

作者：

Chlosta, S

Fishman, DS

Harrington, L

Johnson, EE

Knutson, MD

Wessling-Resnick, M

Cherayil, BJ

机构：

[1] Massachusetts Gen Hosp, Pediat Gastroenterol Unit, Charlestown, MA 02129 USA

[2] Harvard Univ, Sch Med, Charlestown, MA USA

[3] Harvard Univ, Sch Publ Hlth, Dept Genet & Complex Dis, Boston, MA 02115 USA

[4] Charite, Dept Med Microbiol & Immunol & Infect, Berlin, Germany

[5] Childrens Hosp, Div Pediat Gastroenterol & Nutr, Boston, MA 02115 USA

[6] Univ Florida, Dept Food Sci & Human Nutr, Gainesville, FL 32611 USA

来源：

INFECTION AND IMMUNITY | 2006年 / 74卷 / 05期

关键词：

D O I：

10.1128/IAI.74.5.3065-3067.2006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We investigated the influence of the macrophage iron exporter ferroportin and its ligand hepcidin on intracellular Salmonella growth. Elevated ferroportin expression inhibited bacterial multiplication; hepcidin-induced ferroportin down-regulation enhanced it. Expression analysis of iron-responsive Salmonella genes indicated ferroportin-mediated iron deprivation. These results demonstrate a role for ferroportin in antimicrobial resistance.

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收藏

页码：3065 / 3067

页数：3

相关论文

共 29 条

[1] A novel mammalian iron-regulated protein involved in intracellular iron metabolism [J].

Abboud, S ;

Haile, DJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (26) :19906-19912

[2] Expression of ferroportin in hemochromatosis liver [J].

Adams, PC ;

Barbin, YP ;

Khan, ZA ;

Chakrabarti, S .

BLOOD CELLS MOLECULES AND DISEASES, 2003, 31 (02) :256-261

[3] Ferroportin 1 (SCL40A1) variant associated with iron overload in African-Americans [J].

Beutler, E ;

Barton, JC ;

Felitti, VJ ;

Gelbart, T ;

West, C ;

Lee, PL ;

Waalen, J ;

Vulpe, C .

BLOOD CELLS MOLECULES AND DISEASES, 2003, 31 (03) :305-309

[4] Comparative studies of duodenal and macrophage ferroportin proteins [J].

Canonne-Hergaux, F ;

Donovan, A ;

Delaby, C ;

Wang, HJ ;

Gros, P .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2006, 290 (01) :G156-G163

[5] The molecular basis of ferroportin-linked hemochromatosis [J].

De Domenico, I ;

Ward, DM ;

Nemeth, E ;

Vaughn, MB ;

Musci, G ;

Ganz, T ;

Kaplan, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (25) :8955-8960

[6] Presence of the iron exporter ferroportin at the plasma membrane of macrophages is enhanced by iron loading and down-regulated by hepcidin [J].

Delaby, C ;

Pilard, N ;

Gonçalves, AS ;

Beaumont, C ;

Canonne-Hergaux, F .

BLOOD, 2005, 106 (12) :3979-3984

[7] Resistance to hepcidin is conferred by hemochromatosis-associated mutations of ferroportin [J].

Drakesmith, H ;

Schimanski, LM ;

Ormerod, E ;

Merryweather-Clarke, AT ;

Viprakasit, V ;

Edwards, JP ;

Sweetland, E ;

Bastin, JM ;

Cowley, D ;

Chinthammitr, Y ;

Robson, KJH ;

Townsend, ARM .

BLOOD, 2005, 106 (03) :1092-1097

[8] Divalent-metal transport by NRAMP proteins at the interface of host-pathogen interactions [J].

Forbes, JR ;

Gros, P .

TRENDS IN MICROBIOLOGY, 2001, 9 (08) :397-403

[9] Association of pulmonary tuberculosis with increased dietary iron [J].

Gangaidzo, IT ;

Moyo, VM ;

Mvundura, E ;

Aggrey, G ;

Murphree, NL ;

Khumalo, H ;

Saungweme, T ;

Kasvosve, I ;

Gomo, ZAR ;

Rouault, T ;

Boelaert, JR ;

Gordeuk, VR .

JOURNAL OF INFECTIOUS DISEASES, 2001, 184 (07) :936-939

[10] Associations of iron overload in Africa with hepatocellular carcinoma and tuberculosis: Strachan's 1929 thesis revisited [J].

Gordeuk, VR ;

McLaren, CE ;

MacPhail, AP ;

Deichsel, G ;

Bothwell, TH .

BLOOD, 1996, 87 (08) :3470-3476