Tandem Nazarov cyclization-Michael addition sequence catalyzed by an Ir(III) complex

被引：85

作者：

Janka, M

He, W

Haedicke, IE

Fronczek, FR

Frontier, AJ ^{[1
]}

Eisenberg, R

机构：

[1] Univ Rochester, Dept Chem, Rochester, NY 14627 USA

[2] Louisiana State Univ, Dept Chem, Baton Rouge, LA 70803 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 16期

关键词：

D O I：

10.1021/ja058772o

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first examples of a tandem Nazarov cyclization/Michael addition process are described. The sequence is efficiently catalyzed by Ir[Me(CO)(dppe)(DIB)]2+ and occurs with high diastereoselectivity, creating three contiguous stereocenters. The mechanistic factors controlling the reactivity and diastereoselectivity are discussed. Copyright © 2006 American Chemical Society.

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页码：5312 / 5313

页数：2

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