Immune Parameters Correlate with Protection Against Ebola Virus Infection in Rodents and Nonhuman Primates

被引：113

作者：

Wong, Gary ^{[1
,2
]}

Richardson, Jason S. ^{[1
]}

Pillet, Stephane ^{[1
]}

Patel, Ami ^{[1
,2
]}

Qiu, Xiangguo ^{[1
]}

Alimonti, Judie ^{[1
]}

Hogan, Jeff ^{[3
]}

Zhang, Yi ^{[4
]}

Takada, Ayato ^{[5
]}

Feldmann, Heinz ^{[2
,6
]}

Kobinger, Gary P. ^{[1
,2
,7
]}

机构：

[1] Publ Hlth Agcy Canada, Special Pathogens Program, Natl Microbiol Lab, Winnipeg, MB R3E 3R2, Canada

[2] Univ Manitoba, Dept Med Microbiol, Winnipeg, MB R3E 0J9, Canada

[3] Univ Georgia, Dept Anat & Radiol, Dept Infect Dis, Athens, GA 30602 USA

[4] Univ Michigan, Dept Immunol, Blood & Marrow Transplant Program, Ann Arbor, MI 48109 USA

[5] Hokkaido Univ, Div Global Epidemiol, Res Ctr Zoonosis Control, Sapporo, Hokkaido 0010020, Japan

[6] NIAID, Virol Lab, Div Intramural Res, NIH,Rocky Mt Labs, Hamilton, MT 59840 USA

[7] Univ Manitoba, Dept Immunol, Winnipeg, MB R3E 0T5, Canada

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2012年 / 4卷 / 158期

关键词：

EQUINE ENCEPHALITIS-VIRUS; CYTOTOXIC T-LYMPHOCYTES; VACCINE PROTECTS; GUINEA-PIGS; HEMORRHAGIC-FEVER; RECOMBINANT ADENOVIRUSES; MONOCLONAL-ANTIBODIES; CELL RESPONSES; TH2; RESPONSES; IMMUNIZATION;

D O I：

10.1126/scitranslmed.3004582

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Ebola virus causes severe hemorrhagic fever in susceptible hosts. Currently, no licensed vaccines or treatments are available; however, several experimental vaccines have been successful in protecting rodents and nonhuman primates (NHPs) from the lethal Zaire ebolavirus (ZEBOV) infection. The objective of this study was to evaluate immune responses correlating with survival in these animals after lethal challenge with ZEBOV. Knockout mice with impaired ability to generate normal T and/or B cell responses were vaccinated and challenged with ZEBOV. Vaccine-induced protection in mice was mainly mediated by B cells and CD4(+) T cells. Vaccinated, outbred guinea pigs and NHPs demonstrated the highest correlation between survival and levels of total immunoglobulin G (IgG) specific to the ZEBOV glycoprotein (ZGP). These results highlight the relevance of total ZGP-specific IgG levels as a meaningful correlate of protection against ZEBOV exposure.

引用

页数：10

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