Angiogenic factors in bone local environment

被引：342

作者：

Chim, Shek Man ^{[1
]}

Tickner, Jennifer ^{[1
]}

Chow, Siu To ^{[1
]}

Kuek, Vincent ^{[1
]}

Guo, Baosheng ^{[2
]}

Zhang, Ge ^{[2
]}

Rosen, Vicki ^{[3
]}

Erber, Wendy ^{[4
]}

Xu, Jiake ^{[1
]}

机构：

[1] Univ Western Australia, Mol Lab, Sch Pathol & Lab Med, Nedlands, WA 6009, Australia

[2] Hong Kong Baptist Univ, Inst Advancing Translat Med Bone & Joint Dis, Sch Chinese Med, Hong Kong, Hong Kong, Peoples R China

[3] Harvard Univ, Sch Dent Med, Boston, MA 02115 USA

[4] Univ Western Australia, Translat Canc Lab, Sch Pathol & Lab Med, Nedlands, WA 6009, Australia

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2013年 / 24卷 / 03期

基金：

中国国家自然科学基金; 英国医学研究理事会;

关键词：

Bone remodeling; Angiogenesis; EGF-like; Bone remodeling compartment; ENDOTHELIAL GROWTH-FACTOR; OSTEOCLAST DIFFERENTIATION FACTOR; COLONY-STIMULATING FACTOR; NF-KAPPA-B; CHICK CHORIOALLANTOIC MEMBRANE; ACTIVATED PROTEIN-KINASE; MESENCHYMAL STEM-CELLS; VEGF-A EXPRESSION; ADULT HUMAN BONE; FACTOR RECEPTOR;

D O I：

10.1016/j.cytogfr.2013.03.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Angiogenesis plays an important role in physiological bone growth and remodeling, as well as in pathological bone disorders such as fracture repair, osteonecrosis, and tumor metastasis to bone. Vascularization is required for bone remodeling along the endosteal surface of trabecular bone or Haversian canals within the cortical bone, as well as the homeostasis of the cartilage-subchondral bone interface. Angiogenic factors, produced by cells from a basic multicellular unit (BMU) within the bone remodeling compartment (BRC) regulate local endothelial cells and pericytes. In this review, we discuss the expression and function of angiogenic factors produced by osteoclasts, osteoblasts and osteocytes in the BMU and in the cartilage-subchondral bone interface. These include vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), BMP7, receptor activator of NF-kappa B ligand (RANKL) and epidermal growth factor (EGF)-like family members. In addition, the expression of EGFL2, EGFL3, EGFL5, EGFL6, EGFL7, EGFL8 and EGFL9 has been recently identified in the bone local environment, giving important clues to their possible roles in angiogenesis. Understanding the role of angiogenic factors in the bone microenvironment may help to develop novel therapeutic targets and diagnostic biomarkers for bone and joint diseases, such as osteoporosis, osteonecrosis, osteoarthritis, and delayed fracture healing. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：297 / 310

页数：14

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