Syntheses and antifilarial profile of 5-amino and 5,8-diaminoisoquinoline derivatives: A new class of antifilarial agents

被引：30

作者：

Srivastava, SK

Chauhan, PMS

Agarwal, SK

Bhaduri, AP

Singh, SN

Fatma, N

Chatterjee, RK

Bose, C

Srivastava, VML

机构：

[1] CENT DRUG RES INST,DIV MED CHEM,LUCKNOW 226001,UTTAR PRADESH,INDIA

[2] CENT DRUG RES INST,DIV PARASITOL,LUCKNOW 226001,UTTAR PRADESH,INDIA

[3] CENT DRUG RES INST,DIV BIOCHEM,LUCKNOW 226001,UTTAR PRADESH,INDIA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 22期

关键词：

D O I：

10.1016/S0960-894X(96)00458-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The syntheses of 5-amino (4-12,15) and 5,g-diamino(16-17) isoquinoline derivatives, their antifilarial activity and their effect on metabolic activities of filariids are delineated. Some of the screened compounds have shown promising filaricidal response against Acanthocheilonema viteae in rodents. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：2623 / 2628

页数：6

共 13 条

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[2]

BOSE C, 1996, IN PRESS MED SCI RES

[3]

CAMPBELL W C, 1985, Parasitology Today, V1, P10, DOI 10.1016/0169-4758(85)90100-0

[4]

CHAUHAN PMS, 1993, INDIAN J CHEM B, V32, P858