The photocatalytic process as a tool to identify metabolitic products formed from dopant substances: the case of buspirone

被引：38

作者：

Calza, P ^{[1
]}

Pazzi, M ^{[1
]}

Medana, C ^{[1
]}

Baiocchi, C ^{[1
]}

Pelizzetti, E ^{[1
]}

机构：

[1] Univ Turin, Dipartimento Chim Analit, I-10125 Turin, Italy

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2004年 / 35卷 / 01期

关键词：

buspirone; metabolites; doping control; photocatalysis;

D O I：

10.1016/j.jpba.2004.01.001

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The photocatalytic transformation of buspirone, an analgesic anxiolytic drug, and the formation of intermediates products have been evaluated by adopting titanium dioxide as a photocatalyst. Several molecules resulting from buspirone degradation have been identified and characterized by using HPLC/MS/MS technique. The main intermediates formed in these experimental conditions agree with the major buspirone metabolites found "in vivo" on rats and horses: hydroxy and dihydroxy-buspirone, despyrimidinyl buspirone and 1-pyrimidinyl piperazine. This shows that the photocatalytic system could provide in the present case a useful simulation of the metabolic transformation of dopant substances. Moreover, some more oxidized species have been recognized with the photocatalytic process, and this could offer a suggestion for yet to come metabolism studies. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：9 / 19

页数：11

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