Sex differences and estrogen modulation of the cellular immune response after injury

被引：79

作者：

Bird, Melanie D. ^{[1
,2
,4
]}

Karavitis, John ^{[1
,3
,4
]}

Kovacs, Elizabeth J. ^{[1
,2
,3
,4
]}

机构：

[1] Loyola Univ, Med Ctr, Stritch Sch Med, Alcohol Res Program, Maywood, IL 60153 USA

[2] Loyola Univ, Med Ctr, Dept Surg, Maywood, IL 60153 USA

[3] Loyola Univ, Med Ctr, Dept Cell Biol Neurobiol & Anat, Maywood, IL 60153 USA

[4] Loyola Univ, Med Ctr, Burn & Shock Trauma Inst, Maywood, IL 60153 USA

来源：

CELLULAR IMMUNOLOGY | 2008年 / 252卷 / 1-2期

基金：

美国国家卫生研究院;

关键词：

estrogen; testosterone; macrophage; neutrophil; T cell; injury; burn; trauma-hemorrhage; cytokines; immunity; inflammation;

D O I：

10.1016/j.cellimm.2007.09.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cell-mediated immunity is extremely important for resolution of infection and for proper healing from injury. However, the cellular immune response is dysregulated following injuries such as burn and hemorrhage. Sex hormones are known to regulate immunity, and a well-documented dichotomy exists in the immune response to injury between the sexes. This disparity is caused by differences in immune cell activation, infiltration, and cytokine production during and after injury. Estrogen and testosterone can positively or negatively regulate the cellular immune response either by aiding in resolution or by compounding the morbidity and mortality. It is apparent that the hormonal dysregulation is dependent not only on the type of injury sustained but also the amount of circulating hormones. Therefore, it may be possible to design sex-specific therapies to improve immunological function and patient outcome. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：57 / 67

页数：11

共 126 条

[1] Estrogens inhibit angiotensin II-induced leukocyte-endothelial cell interactions in vivo via rapid endothelial nitric oxide synthase and cyclooxygenase activation [J].