Rapid Enantiomeric Excess and Concentration Determination Using Simple Racemic Metal Complexes

被引：36

作者：

Nieto, Sonia ^{[1
]}

Lynch, Vincent M. ^{[1
]}

Anslyn, Eric V. ^{[1
]}

Kim, Hyunwoo ^{[2
]}

Chin, Jik ^{[2
]}

机构：

[1] Univ Texas Austin, Dept Chem & Biochem, Austin, TX 78712 USA

[2] Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 22期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1021/ol802085j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Racemic-metal complexes were used to determine identity, enantiomeric excess, and concentration of chiral diamines using metal-to-ligand charge transfer bands in circular dichroism spectroscopy. It takes under just 2 min per sample to determine [G](t) and %R with tolerable errors (19% and 4%, respectively). The simplicity of the achiral receptors employed confers to this technique great potential for high-throughput screening.

引用

页码：5167 / 5170

页数：4

共 47 条

[41] A high-throughput screening protocol for fast evaluation of enantioselective catalysts [J].

Wolf, C ;

Hawes, PA .

JOURNAL OF ORGANIC CHEMISTRY, 2002, 67 (08) :2727-2729

[42] Catalytic enantioselective ene reactions of imines:: a simple approach for the formation of optically active α-amino acids [J].

Yao, SL ;

Fang, XM ;

Jorgensen, KA .

CHEMICAL COMMUNICATIONS, 1998, (22) :2547-2548

[43] Chirality-responsive helical polymers [J].

Yashima, Eiji ;

Maeda, Katsuhiro .

MACROMOLECULES, 2008, 41 (01) :3-12

[44] Improvements in quantitative chiral determinations using the mass spectrometric kinetic method [J].

Young, Brandy L. ;

Cooks, R. Graham .

INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 2007, 267 (1-3) :199-204

[45] Guidelines in implementing enantioselective indicator-displacement assays for α-hydroxycarboxylates and diols [J].

Zhu, L ;

Zhong, ZL ;

Anslyn, EV .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (12) :4260-4269

[46] Facile quantification of enantiomeric excess and concentration with indicator-displacement assays:: An example in the analyses of α-hydroxyacids [J].

Zhu, L ;

Anslyn, EV .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (12) :3676-3677

[47] Two methods for the determination of enantiomeric excess and concentration of a chiral sample with a single spectroscopic measurement [J].

Zhu, Lei ;

Shabbir, Shagufta H. ;

Anslyn, Eric V. .

CHEMISTRY-A EUROPEAN JOURNAL, 2007, 13 (01) :99-104

← 1 2 3 4 5 →