Microbial manipulation as primary therapy for Crohn's disease

被引：4

作者：

Longman, Randy S. ^{[1
]}

Swaminath, Arun ^{[1
]}

机构：

[1] Columbia Univ, Dept Med, Med Ctr, Div Digest & Liver Dis, New York, NY 10032 USA

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2013年 / 19卷 / 10期

关键词：

Inflammatory bowel disease; Rifaximin; Microbiome; INFLAMMATORY BOWEL DISEASES; PLACEBO-CONTROLLED TRIAL; DOUBLE-BLIND; ANTIMYCOBACTERIAL THERAPY; ANTIBIOTIC-THERAPY; RIFAXIMIN; CLARITHROMYCIN; CLOFAZIMINE;

D O I：

10.3748/wjg.v19.i10.1513

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

While antimicrobials are clinically effective in preventing post-operative recurrence, the role for antibiotics in primary therapy for Crohn's disease (CD) remains unclear. The recent multicenter phase 2 trial by Prantera et al received wide attention because it demonstrated an increase in the week 12 remission rate in patients with moderately active CD treated with rifaximin and renewed interest in microbial manipulation as primary therapy for CD. In this commentary, we discuss aspects of durability, immune cell polarization, and safety of microbial manipulation as primary therapy for CD. (C) 2013 Baishideng. All rights reserved.

引用

页码：1513 / 1516

页数：4

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