Diagnostic Value of Regulatory T Cells: A New Facet of a Much Studied Cell Population

被引：14

作者：

Brown, Kathryn

Wong, Wilson ^{[1
]}

机构：

[1] Kings Coll London, MRC Ctr transplantat, Sch Med, Guys Hosp, London SE1 9RT, England

来源：

TRANSPLANTATION | 2008年 / 86卷 / 11期

基金：

英国医学研究理事会;

关键词：

Regulatory T cells; Rejection; Tolerance; Diagnostic value;

D O I：

10.1097/TP.0b013e31818f3d2a

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

FOXP3 has emerged as the most suitable marker for Treg and has been studied in both experimental and clinical transplantation. Biopsy samples have been stained for FOXP3(+) cells whereas FOXP3 messenger RNA levels have been measured in blood and urine samples after transplantation. Although not unanimous, some studies have suggested that FOXP3 is associated with better outcome and can also serve as a marker of rejection. Routine staining of FOXP3(+) cells in biopsy samples and FOXP3 messenger RNA levels in urine of kidney transplant patients may determine each patient's immunological profile, enabling less immunosuppression to be given to those at lower risk.

引用

收藏

页码：1485 / 1491

页数：7

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