The microbiota in inflammatory bowel disease: friend, bystander, and sometime-villain

被引：27

作者：

Shanahan, Fergus ^{[1
,2
]}

机构：

[1] Natl Univ Ireland Univ Coll Cork, Alimentary Pharmabiot Ctr, Cork, Ireland

[2] Natl Univ Ireland Univ Coll Cork, Dept Med, Cork, Ireland

来源：

NUTRITION REVIEWS | 2012年 / 70卷

基金：

爱尔兰科学基金会;

关键词：

Crohn's disease; inflammatory bowel disease; ulcerative colitis; GUT MICROBIOTA; CROHNS-DISEASE; ULCERATIVE-COLITIS; DIET; COMMENSAL; BACTERIA; HEALTH; INTERLEUKIN-10; PATHOGENESIS; HOMEOSTASIS;

D O I：

10.1111/j.1753-4887.2012.00502.x

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 [营养与食品卫生学];

摘要：

Ulcerative colitis and Crohn's disease, collectively known as inflammatory bowel disease, represent the heterogeneous outcome of three colliding influences: genetic risk factors, environmental modifiers, and immune effector mechanisms of tissue injury. The nature of these inputs is complex, with each having distinct and overlapping contributions to ulcerative colitis and Crohn's disease. Identification of specific genetic risk factors has improved the understanding of specific pathways to disease, but the primacy of environmental or lifestyle factors linked to changes in the gut microbiota, particularly in early life, is increasingly evident. Clarification of the molecular basis of host-microbe interactions in health and in susceptible individuals promises novel therapeutic strategies.

引用

页码：S31 / S37

页数：7

共 71 条

[1]

Interactions Between the Host Innate Immune System and Microbes in Inflammatory Bowel Disease [J].

Abraham, Clara ;

Medzhitov, Ruslan .

GASTROENTEROLOGY, 2011, 140 (06) :1729-1737

[2]

Detection of Mycobacterium avium subspecies paratuberculosis from patients with Crohn's disease using nucleic acid-based techniques:: A systematic review and meta-analysis [J].

Abubakar, I. ;

Myhill, D. ;

Aliyu, S. H. ;

Hunter, P. R. .

INFLAMMATORY BOWEL DISEASES, 2008, 14 (03) :401-410

[3]

ATP drives lamina propria TH17 cell differentiation [J].

Atarashi, Koji ;

Nishimura, Junichi ;

Shima, Tatsuichiro ;

Umesaki, Yoshinori ;

Yamamoto, Masahiro ;

Onoue, Masaharu ;

Yagita, Hideo ;

Ishii, Naoto ;

Evans, Richard ;

Honda, Kenya ;

Takeda, Kiyoshi .

NATURE, 2008, 455 (7214) :808-U10

[4]

Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region [J].

Barrett, Jeffrey C. ;

Lee, James C. ;

Lees, Charles W. ;

Prescott, Natalie J. ;

Anderson, Carl A. ;

Phillips, Anne ;

Wesley, Emma ;

Parnell, Kirstie ;

Zhang, Hu ;

Drummond, Hazel ;

Nimmo, Elaine R. ;

Massey, Dunecan ;

Blaszczyk, Kasia ;

Elliott, Timothy ;

Cotterill, Lynn ;

Dallal, Helen ;

Lobo, Alan J. ;

Mowat, Craig ;

Sanderson, Jeremy D. ;

Jewell, Derek P. ;

Newman, William G. ;

Edwards, Cathryn ;

Ahmad, Tariq ;

Mansfield, John C. ;

Satsangi, Jack ;

Parkes, Miles ;

Mathew, Christopher G. ;

Donnelly, Peter ;

Peltonen, Leena ;

Blackwell, Jenefer M. ;

Bramon, Elvira ;

Brown, Matthew A. ;

Casas, Juan P. ;

Corvin, Aiden ;

Craddock, Nicholas ;

Deloukas, Panos ;

Duncanson, Audrey ;

Jankowski, Janusz ;

Markus, Hugh S. ;

McCarthy, Mark I. ;

Palmer, Colin N. A. ;

Plomin, Robert ;

Rautanen, Anna ;

Sawcer, Stephen J. ;

Samani, Nilesh ;

Trembath, Richard C. ;

Viswanathan, Ananth C. ;

Wood, Nicholas ;

Spencer, Chris C. A. ;

Bellenguez, Celine .

NATURE GENETICS, 2009, 41 (12) :1330-U99

[5]

Disorders of a modern lifestyle: reconciling the epidemiology of inflammatory bowel diseases [J].

Bernstein, Charles N. ;

Shanahan, Fergus .

GUT, 2008, 57 (09) :1185-1191

[6]

Biedermann L, 2011, PROGRAM ABSTRACTS DI

[7]

ESSAY What are the consequences of the disappearing human microbiota? [J].

Blaser, Martin J. ;

Falkow, Stanley .

NATURE REVIEWS MICROBIOLOGY, 2009, 7 (12) :887-894

[8]

Commensal Bacteroides Species Induce Colitis in Host-Genotype-Specific Fashion in a Mouse Model of Inflammatory Bowel Disease [J].

Bloom, Seth M. ;

Bijanki, Vinieth N. ;

Nava, Gerardo M. ;

Sun, Lulu ;

Malvin, Nicole P. ;

Donermeyer, David L. ;

Dunne, W. Michael, Jr. ;

Allen, Paul M. ;

Stappenbeck, Thaddeus S. .

CELL HOST & MICROBE, 2011, 9 (05) :390-403

[9]

A phase I trial with Transgenic bacteria expressing interleukin-10 in Crohn's disease [J].

Braat, Henri ;

Rottiers, Pieter ;

Hommes, Daniel W. ;

Huyghebaert, Nathalie ;

Remaut, Erik ;

Remon, Jean-Paul ;

Van Deventer, Sander J. H. ;

Neirynck, Sabine ;

Peppelenbosch, Maikel P. ;

Steidler, Lothar .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2006, 4 (06) :754-759

[10]

Virus-Plus-Susceptibility Gene Interaction Determines Crohn's Disease Gene Atg16L1 Phenotypes in Intestine [J].

Cadwell, Ken ;

Patel, Khushbu K. ;

Maloney, Nicole S. ;

Liu, Ta-Chiang ;

Ng, Aylwin C. Y. ;

Storer, Chad E. ;

Head, Richard D. ;

Xavier, Ramnik ;

Stappenbeck, Thaddeus S. ;

Virgin, Herbert W. .

CELL, 2010, 141 (07) :1135-U64

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