Autophagy protects proximal tubular cells from injury and apoptosis

被引：80

作者：

Kaushal, Gur P. ^{[1
,2
,3
]}

机构：

[1] Cent Arkansas Vet Healthcare Syst, Little Rock, AR 72205 USA

[2] Univ Arkansas Med Sci, Dept Med, Little Rock, AR 72205 USA

[3] Univ Arkansas Med Sci, Dept Biochem, Little Rock, AR 72205 USA

来源：

KIDNEY INTERNATIONAL | 2012年 / 82卷 / 12期

关键词：

ISCHEMIA-REPERFUSION INJURY; EPITHELIAL-CELLS;

D O I：

10.1038/ki.2012.337

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

100201 [内科学]; 100221 [泌尿外科学];

摘要：

Autophagy is upregulated during ischemia-reperfusion (IR)-induced and cisplatin-induced acute kidney injury (AKI). Proximal tubule-specific Atg7 knockout mice exhibited increased renal injury compared with wild-type mice following cisplatin-and IR-induced AKI. Inhibition of autophagy by chloroquine aggravated AKI, whereas upregulation of autophagy by rapamycin recovered lost renal function and histology, further indicating a protective role of autophagy in AKI. These findings reported by Jiang et al. will provide stimulus to further examine the role and mechanism of the enhancement of autophagy in AKI. Kidney International (2012) 82, 1250-1253. doi:10.1038/ki.2012.337

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收藏

页码：1250 / 1253

页数：5

相关论文

共 12 条

[1]

Autophagy in proximal tubules protects against acute kidney injury [J].

Jiang, Man ;

Wei, Qingqing ;

Dong, Guie ;

Komatsu, Masaaki ;

Su, Yunchao ;

Dong, Zheng .

KIDNEY INTERNATIONAL, 2012, 82 (12) :1271-1283

[2]

Autophagy Is a Renoprotective Mechanism During in Vitro Hypoxia and in Vivo Ischemia-Reperfusion Injury [J].

Jiang, Man ;

Liu, Kebin ;

Luo, Jia ;

Dong, Zheng .

AMERICAN JOURNAL OF PATHOLOGY, 2010, 176 (03) :1181-1192

[3]

Tor Directly Controls the Atg1 Kinase Complex To Regulate Autophagy [J].

Kamada, Yoshiaki ;

Yoshino, Ken-ichi ;

Kondo, Chika ;

Kawamata, Tomoko ;

Oshiro, Noriko ;

Yonezawa, Kazuyoshi ;

Ohsumi, Yoshinori .

MOLECULAR AND CELLULAR BIOLOGY, 2010, 30 (04) :1049-1058

[4]

Autophagy delays apoptosis in renal tubular epithelial cells in cisplatin cytotoxicity [J].

Kaushal, Gur P. ;

Kaushal, Varsha ;

Herzog, Christian ;

Yang, Cheng .

AUTOPHAGY, 2008, 4 (05) :710-712

[5]

Autophagy Protects the Proximal Tubule from Degeneration and Acute Ischemic Injury [J].

Kimura, Tomonori ;

Takabatake, Yoshitsugu ;

Takahashi, Atsushi ;

Kaimori, Jun-ya ;

Matsui, Isao ;

Namba, Tomoko ;

Kitamura, Harumi ;

Niimura, Fumio ;

Matsusaka, Taiji ;

Soga, Tomoyoshi ;

Rakugi, Hiromi ;

Isaka, Yoshitaka .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2011, 22 (05) :902-913

[6]

Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems [J].

Korolchuk, Viktor I. ;

Menzies, Fiona M. ;

Rubinsztein, David C. .

FEBS LETTERS, 2010, 584 (07) :1393-1398

[7]

The Role of the Mammalian Target Of Rapamycin (mTOR) in Renal Disease [J].

Lieberthal, Wilfred ;

Levine, Jerrold S. .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2009, 20 (12) :2493-2502

[8]

Autophagy plays a critical role in kidney tubule maintenance, aging and ischemia-reperfusion injury [J].

Liu, Shuya ;

Hartleben, Bjoern ;

Kretz, Oliver ;

Wiech, Thorsten ;

Igarashi, Peter ;

Mizushima, Noboru ;

Walz, Gerd ;

Huber, Tobias B. .

AUTOPHAGY, 2012, 8 (05) :826-837

[9]

The Role of Atg Proteins in Autophagosome Formation [J].

Mizushima, Noboru ;

Yoshimori, Tamotsu ;

Ohsumi, Yoshinori .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 27, 2011, 27 :107-132

[10]

Autophagy in mammalian development and differentiation [J].

Mizushima, Noboru ;

Levine, Beth .

NATURE CELL BIOLOGY, 2010, 12 (09) :823-830