The visualization of T cell responses

被引：1

作者：

Barbara, JAJ ^{[1
]}

Gilot, BJ ^{[1
]}

Hara, M ^{[1
]}

Van Maurik, A ^{[1
]}

Jones, ND ^{[1
]}

Turvey, SE ^{[1
]}

Wood, KJ ^{[1
]}

机构：

[1] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Surg, Oxford OX3 9DU, England

来源：

TRANSPLANTATION | 1999年 / 67卷 / 12期

基金：

英国惠康基金;

关键词：

D O I：

10.1097/00007890-199906270-00002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Transplanting allogeneic grafts is still significantly hampered by the rejection process, despite the use of powerful immunosuppressive agents. The T cell is recognized as playing a central role in the process of rejection, and it is believed that graft tolerance will ultimately be achieved by immunological manipulation of this cell (1, 2). As immunologists strive to define the role of the T cell in the fundamental processes of immunity and tolerance, new methods are emerging that will facilitate visualization of the T cells directly involved in the rejection response (3, 4). This overview addresses the visualization of T cell responses as made possible by these technological developments.

引用

页码：1508 / 1514

页数：7

共 56 条

[1] Phenotypic analysis of antigen-specific T lymphocytes [J].

Altman, JD ;

Moss, PAH ;

Goulder, PJR ;

Barouch, DH ;

McHeyzerWilliams, MG ;

Bell, JI ;

McMichael, AJ ;

Davis, MM .

SCIENCE, 1996, 274 (5284) :94-96

[2] THE DEGREE OF CD8 DEPENDENCE OF CYTOLYTIC T-CELL PRECURSORS IS DETERMINED BY THE NATURE OF THE T-CELL RECEPTOR (TCR) AND INFLUENCES NEGATIVE SELECTION IN TCR-TRANSGENIC MICE [J].

AUPHAN, N ;

CURNOW, J ;

GUIMEZANES, A ;

LANGLET, C ;

MALISSEN, B ;

MELLOR, A ;

SCHMITTVERHULST, AM .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1994, 24 (07) :1572-1577

[3] ON THE CELLULAR BASIS OF IMMUNOLOGICAL T-CELL MEMORY [J].

BRUNO, L ;

KIRBERG, J ;

VONBOEHMER, H .

IMMUNITY, 1995, 2 (01) :37-43

[4]

BUFERNE M, 1992, J IMMUNOL, V148, P657

[5] Massive expansion of antigen-specific CD8+ T cells during an acute virus infection [J].

Butz, EA ;

Bevan, MJ .

IMMUNITY, 1998, 8 (02) :167-175

[6] Direct visualization of antigen-specific CD8+ T cells during the primary immune response to Epstein-Barr virus in vivo [J].

Callan, MFC ;

Tan, L ;

Annels, N ;

Ogg, GS ;

Wilson, JDK ;

O'Callaghan, CA ;

Steven, N ;

McMichael, AJ ;

Rickinson, AB .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (09) :1395-1402

[7]

Chen HF, 1996, J IMMUNOL, V157, P4297

[8] T-CELL RECEPTOR CROSS-LINKING TRANSIENTLY STIMULATES ADHESIVENESS THROUGH LFA-1 [J].

DUSTIN, ML ;

SPRINGER, TA .

NATURE, 1989, 341 (6243) :619-624

[9]

FESTENSTEIN H, 1973, TRANSPLANT REV-DENMA, V15, P62

[10] CORRELATIONS BETWEEN T-CELL SPECIFICITY AND THE STRUCTURE OF THE ANTIGEN RECEPTOR [J].

FINK, PJ ;

MATIS, LA ;

MCELLIGOTT, DL ;

BOOKMAN, M ;

HEDRICK, SM .

NATURE, 1986, 321 (6067) :219-226

← 1 2 3 4 5 6 →