Oral contraceptives highlight the genotype-specific association between serum phospholipids and activated factor VII

被引:7
作者
Mariani, G
Conard, J
Bernardi, F
Bertina, R
Garcia, VV
Prydz, H
Samama, M
Sandset, PM
Puopolo, N
Ciarla, MV
Poso, R
Di Nucci, GD
Ceci, F
Marchetti, G
机构
[1] Palermo Univ Hosp, Hematol & Bone Marrow Transplantat Unit, I-90127 Palermo, Italy
[2] Univ Roma La Sapienza, Dept Human Biopathol, Rome, Italy
[3] Univ Ferrara, Dept Biochem & Mol Biol, I-44100 Ferrara, Italy
[4] Leiden Univ, Med Ctr, Leiden, Netherlands
[5] Murcia Univ Hosp, Dept Hematol, Murcia, Spain
[6] Univ Oslo, Ctr Biotechnol, Oslo, Norway
[7] Hop Hotel Dieu, F-75181 Paris, France
[8] Ullevaal Univ Hosp, Oslo, Norway
[9] Natl Inst Hlth, Rome, Italy
关键词
factor VII; activated factor VII; phospholipids; factor VII genotype;
D O I
10.1161/01.ATV.19.8.2024
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The present analysis was undertaken to study the effect of oral contraceptive (OC) use on activated factor VII (FVIIa) in subjects characterized by FVII genotypes, with the further aim of evaluating the role of lipids in this pharmacological interaction. In OC users (n=42) and nonusers (n=130) of comparable age, we examined the FVII phenotypic variables (FVII coagulant activity [FVIIc], FVII antigen, and FVIIa), FVII genotypes (the 353R/Q and 5'F7 polymorphisms analyzed in combination; alleles M1/M2 and A1/A2, respectively), and a number of lipid and lipoprotein parameters: serum concentrations of total cholesterol (chol), low density lipoprotein and high density lipoprotein-chol, triglycerides, phospholipids (PhLs), apolipoprotein Al, and lipoprotein(a). PhLs, triglycerides, apolipoprotein Al, chol, FVII antigen, FVIIc, and high density lipoprotein-chol levels were shown to be statistically higher in users than nonusers. FVII levels, particularly those of FVIIa and FVIIc, were much higher in homozygotes for the Al and MI alleles (A11 M11), especially in OC users. A strong association was found between PhL and FVIIa: in the multiple regression analysis, women taking OCs who had elevated PhL concentrations also had very high levels of FVIIa, but only if their genotype was All Mil. These results indicate that the increased FVII levels in OC users depend on the FVII genotype and that high PhL concentrations predict very high levels of FVIIa and FVIIc.
引用
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页码:2024 / 2028
页数:5
相关论文
共 66 条
[1]  
Bernardi F, 1996, ARTERIOSCL THROM VAS, V16, P72
[2]   Contribution of factor VII genotype to activated FVII levels - Differences in genotype frequencies between northern and southern European populations [J].
Bernardi, F ;
Arcieri, P ;
Bertina, RM ;
Chiarotti, F ;
Corral, J ;
Pinotti, M ;
Prydz, H ;
Samama, M ;
Sandset, PM ;
Strom, R ;
Garcia, VV ;
Mariani, G .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1997, 17 (11) :2548-2553
[3]   ENHANCEMENT BY FACTOR-V LEIDEN MUTATION OF RISK OF DEEP-VEIN THROMBOSIS ASSOCIATED WITH ORAL-CONTRACEPTIVES CONTAINING 3RD-GENERATION PROGESTAGEN [J].
BLOEMENKAMP, KWM ;
ROSENDAAL, FR ;
HELMERHORST, FM ;
BULLER, HR ;
VANDENBROUCKE, JP .
LANCET, 1995, 346 (8990) :1593-1596
[4]  
BOTTIGER LE, 1980, LANCET, V1, P1097
[5]   INTERRELATIONSHIP OF PLASMA TRIGLYCERIDE AND COAGULANT FACTOR-VII LEVELS IN NORMOTRIGLYCERIDEMIC HYPERCHOLESTEROLEMIA [J].
BRUCKERT, E ;
DESOUSA, JC ;
GIRAL, P ;
SORIA, C ;
CHAPMAN, MJ ;
CAEN, J ;
DEGENNES, JL .
ATHEROSCLEROSIS, 1989, 75 (2-3) :129-134
[6]   RISK-FACTORS FOR ACUTE MYOCARDIAL-INFARCTION IN WOMEN - EVIDENCE FROM THE ROYAL-COLLEGE-OF-GENERAL-PRACTITIONERS ORAL CONTRACEPTION STUDY [J].
CROFT, P ;
HANNAFORD, PC .
BRITISH MEDICAL JOURNAL, 1989, 298 (6667) :165-168
[7]   COMPARATIVE-STUDIES OF 30-MU-G ETHINYL ESTRADIOL COMBINED WITH GESTODENE AND DESOGESTREL ON BLOOD-COAGULATION, FIBRINOLYSIS, AND PLATELETS [J].
DALY, L ;
BONNAR, J .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1990, 163 (01) :430-437
[8]   HEMOSTASIS PROFILE IN WOMEN TAKING LOW-DOSE ORAL-CONTRACEPTIVES [J].
DAVID, JL ;
GASPARD, UJ ;
GILLAIN, D ;
RASKINET, R ;
LEPOT, MR .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1990, 163 (01) :420-423
[9]  
DESOUSA JC, 1989, HAEMOSTASIS, V19, P125
[10]   ASSOCIATION BETWEEN COAGULATION FACTOR-VII AND FACTOR-X WITH TRIGLYCERIDE RICH LIPOPROTEINS [J].
DESOUSA, JC ;
SORIA, C ;
AYRAULTJARRIER, M ;
PASTIER, D ;
BRUCKERT, E ;
AMIRAL, J ;
BEREZIAT, G ;
CAEN, JP .
JOURNAL OF CLINICAL PATHOLOGY, 1988, 41 (09) :940-944