High-Density Lipoprotein and Residual Cardiovascular Risk De Minimis Non Curat Medicus or the COURAGE to be SMART?

被引：2

作者：

Genest, Jacques ^{[1
]}

机构：

[1] McGill Univ, Royal Victoria Hosp, Ctr Hlth, Montreal, PQ H3A 1A1, Canada

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2013年 / 62卷 / 20期

基金：

加拿大健康研究院;

关键词：

HDL cholesterol; LDL cholesterol; secondary prevention; statins; ISCHEMIC-HEART-DISEASE; HDL CHOLESTEROL; STATIN THERAPY; MECHANISMS; OUTCOMES; EVENTS; TRIAL;

D O I：

10.1016/j.jacc.2013.05.087

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Legal scholars and overburdened judges apply the rule of "De minimis non curat praetor" (i.e., the praetor does not concern himself with trifles), which loosely translates as: "don't sweat the small stuff." Should physicians apply this rule to the smallest (and, to many of us, the most noble) of lipoproteins? The study by van de Woestijne et al. (1) in this issue of the Journal suggests that the measurement of high-density lipoprotein cholesterol (HDL-C) in patients with established atherosclerotic cardiovascular disease treated with intensive low-density lipoprotein cholesterol (LDL-C) lowering no longer predicts future cardiovascular events.

引用

页码：1842 / 1844

页数：3

共 23 条

[1]

Low Levels of High-Density Lipoprotein Cholesterol and Increased Risk of Cardiovascular Events in Stable Ischemic Heart Disease Patients A Post-Hoc Analysis From the COURAGE Trial (Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation) [J].

Acharjee, Subroto ;

Boden, William E. ;

Hartigan, Pamela M. ;

Teo, Koon K. ;

Maron, David J. ;

Sedlis, Steven P. ;

Kostuk, William ;

Spertus, John A. ;

Dada, Marcin ;

Chaitman, Bernard R. ;

Mancini, G. B. John ;

Weintraub, William S. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2013, 62 (20) :1826-1833

[2]

The HDL proteome in acute coronary syndromes shifts to an inflammatory profile [J].

Alwaili, Khalid ;

Bailey, Dana ;

Awan, Zuhier ;

Bailey, Swneke D. ;

Ruel, Isabelle ;

Hafiane, Anouar ;

Krimbou, Larbi ;

Laboissiere, Sylvie ;

Genest, Jacques .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2012, 1821 (03) :405-415

[3]

2012 Update of the Canadian Cardiovascular Society Guidelines for the Diagnosis and Treatment of Dyslipidemia for the Prevention of Cardiovascular Disease in the Adult [J].

Anderson, Todd J. ;

Gregoire, Jean ;

Hegele, Robert A. ;

Couture, Patrick ;

Mancini, G. B. John ;

McPherson, Ruth ;

Francis, Gordon A. ;

Poirier, Paul ;

Lau, David C. ;

Grover, Steven ;

Genest, Jacques, Jr. ;

Carpentier, Andre C. ;

Dufour, Robert ;

Gupta, Milan ;

Ward, Richard ;

Leiter, Lawrence A. ;

Lonn, Eva ;

Ng, Dominic S. ;

Pearson, Glen J. ;

Yates, Gillian M. ;

Stone, James A. ;

Ur, Ehud .

CANADIAN JOURNAL OF CARDIOLOGY, 2013, 29 (02) :151-167

[4]

S1P, dihydro-S1P and C24:1-ceramide levels in the HDL-containing fraction of serum inversely correlate with occurrence of ischemic heart disease [J].

Argraves, Kelley M. ;

Sethi, Amar A. ;

Gazzolo, Patrick J. ;

Wilkerson, Brent A. ;

Remaley, Alan T. ;

Tybjaerg-Hansen, Anne ;

Nordestgaard, Borge G. ;

Yeatts, Sharon D. ;

Nicholas, Katherine S. ;

Barth, Jeremy L. ;

Argraves, W. Scott .

LIPIDS IN HEALTH AND DISEASE, 2011, 10

[5]

HDL cholesterol, very low levels of LDL cholesterol, and cardiovascular events [J].

Barter, Philip ;

Gotto, Antonio M. ;

LaRosa, John C. ;

Maroni, Jaman ;

Szarek, Michael ;

Grundy, Scott M. ;

Kastelein, John J. P. ;

Bittner, Vera ;

Fruchart, Jean-Charles .

NEW ENGLAND JOURNAL OF MEDICINE, 2007, 357 (13) :1301-1310

[6]

Molecular mechanisms of vascular effects of High-density lipoprotein: alterations in cardiovascular disease [J].

Besler, Christian ;

Luescher, Thomas F. ;

Landmesser, Ulf .

EMBO MOLECULAR MEDICINE, 2012, 4 (04) :251-268

[7]

Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease [J].

Besler, Christian ;

Heinrich, Kathrin ;

Rohrer, Lucia ;

Doerries, Carola ;

Riwanto, Meliana ;

Shih, Diana M. ;

Chroni, Angeliki ;

Yonekawa, Keiko ;

Stein, Sokrates ;

Schaefer, Nicola ;

Mueller, Maja ;

Akhmedov, Alexander ;

Daniil, Georgios ;

Manes, Costantina ;

Templin, Christian ;

Wyss, Christophe ;

Maier, Willibald ;

Tanner, Felix C. ;

Matter, Christian M. ;

Corti, Roberto ;

Furlong, Clement ;

Lusis, Aldons J. ;

von Eckardstein, Arnold ;

Fogelman, Alan M. ;

Luescher, Thomas F. ;

Landmesser, Ulf .

JOURNAL OF CLINICAL INVESTIGATION, 2011, 121 (07) :2693-2708

[8]

Niacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin Therapy [J].

Boden, William E. ;

Probstfield, Jeffrey L. ;

Anderson, Todd ;

Chaitman, Bernard R. ;

Desvignes-Nickens, Patrice ;

Koprowicz, Kent ;

McBride, Ruth ;

Teo, Koon ;

Weintraub, William .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (24) :2255-2267

[9]

Campbell S, 2013, EXPERT REV CARDIOVAS, V11, P343, DOI [10.1586/erc.13.17, 10.1586/ERC.13.17]

[10]

Novel HDL-directed pharmacotherapeutic strategies [J].

Degoma, Emil M. ;

Rader, Daniel J. .

NATURE REVIEWS CARDIOLOGY, 2011, 8 (05) :266-277

← 1 2 3 →