Recent progress in the tumor necrosis factor-alpha field

被引：122

作者：

Rink, L

Kirchner, H

机构：

[1] Institute of Immunology and Transfusion Medicine, University of Lübeck School of Medicine

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1996年 / 111卷 / 03期

关键词：

tumor necrosis factor receptor; gene polymorphism; autoimmunity; transplantation; infectious diseases;

D O I：

10.1159/000237369

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Tumor necrosis factor (TNF is used synonymously with TNF-alpha) is a pleiotropic cytokine. The effects of TNF were first described in the last century, but the soluble factor was discovered in 1975. Now TNF is one of the most important cytokines investigated by scientists from different fields. This short review briefly summarizes the state of the art and adds the news of the last 2 years. The progress in the field of TNF is focussed on gene organization and transcription, gene polymorphism, biochemistry of TNF, TNF receptors and the biological role of TNF in autoimmune diseases, infectious diseases, transplantation, cancer and TNF functions on endothelial cells.

引用

收藏

页码：199 / 209

页数：11

相关论文

共 120 条

[1] MYCOPLASMA ARTHRITIDIS-DERIVED SUPERANTIGEN INDUCES PROINFLAMMATORY MONOKINE GENE-EXPRESSION IN THE THP-1 HUMAN MONOCYTIC CELL-LINE [J].

ALDACCAK, R ;

MEHINDATE, K ;

HEBERT, J ;

MECHERI, S ;

MOURAD, W ;

RINK, L .

INFECTION AND IMMUNITY, 1994, 62 (06) :2409-2416

[2] STRAIN VARIATION IN TUMOR-NECROSIS-FACTOR INDUCTION BY PARASITES FROM CHILDREN WITH ACUTE FALCIPARUM-MALARIA [J].

ALLAN, RJ ;

BEATTIE, P ;

BATE, C ;

VANHENSBROEK, MB ;

MORRISJONES, S ;

GREENWOOD, BM ;

KWIATKOWSKI, D .

INFECTION AND IMMUNITY, 1995, 63 (04) :1173-1175

[3] G-619, A DUAL THROMBOXANE SYNTHASE INHIBITOR AND THROMBOXANE A(2) RECEPTOR ANTAGONIST, INHIBITS TUMOR-NECROSIS-FACTOR-ALPHA BIOSYNTHESIS [J].

ALTAVILLA, D ;

SQUADRITO, F ;

CANALE, P ;

IOCULANO, M ;

SQUADRITO, G ;

CAMPO, GM ;

SERRANO, M ;

SARDELLA, A ;

URNA, G ;

SPIGNOLI, G ;

CAPUTI, AP .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1995, 286 (01) :31-39

[4]

ALVAREZOSSORIO L, 1995, CYTOKINE, V7, P626

[5] INHIBITION OF THE PRODUCTION AND EFFECTS OF INTERLEUKIN-1 AND TUMOR-NECROSIS-FACTOR-ALPHA IN RHEUMATOID-ARTHRITIS [J].

AREND, WP ;

DAYER, JM .

ARTHRITIS AND RHEUMATISM, 1995, 38 (02) :151-160

[6] TUMOR-NECROSIS-FACTOR-ALPHA INHIBITS SURFACTANT PROTEIN-C GENE-TRANSCRIPTION [J].

BACHURSKI, CJ ;

PRYHUBER, GS ;

GLASSER, SW ;

KELLY, SE ;

WHITSETT, JA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (33) :19402-19407

[7] SERUM LEVELS OF END-PRODUCTS OF NITRIC-OXIDE SYNTHESIS CORRELATE POSITIVELY WITH TUMOR-NECROSIS-FACTOR A AND NEGATIVELY WITH BODY-TEMPERATURE IN PATIENTS WITH POSTOPERATIVE ABDOMINAL SEPSIS [J].

BARTHLEN, W ;

STADLER, J ;

LEHN, NL ;

MIETHKE, T ;

BARTELS, H ;

SIEWERT, JR .

SHOCK, 1994, 2 (06) :398-401

[8] CHIMERIC TUMOR-NECROSIS-FACTOR RECEPTORS WITH CONSTITUTIVE SIGNALING ACTIVITY [J].

BAZZONI, F ;

ALEJOS, E ;

BEUTLER, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (12) :5376-5380

[9]

BIRAGYN A, 1995, J IMMUNOL, V155, P674

[10] METALLOPROTEASES AND SERINE PROTEASES ARE INVOLVED IN THE CLEAVAGE OF THE 2 TUMOR-NECROSIS-FACTOR (TNF) RECEPTORS TO SOLUBLE FORMS IN THE MYELOID CELL-LINES U-937 AND THP-1 [J].

BJORNBERG, F ;

LANTZ, M ;

GULLBERG, U .

SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1995, 42 (04) :418-424

← 1 2 3 4 5 6 7 8 9 10 →