Lung alkaline phosphatase as a marker of fibrosis in chronic interstitial disorders

被引:59
作者
Capelli, A [1 ]
Lusuardi, M [1 ]
Cerutti, CG [1 ]
Donner, CF [1 ]
机构
[1] IRCCS,SALVATORE MAUGERI FDN,DIV PULM DIS,VERUNO,ITALY
关键词
IDIOPATHIC PULMONARY FIBROSIS; BRONCHOALVEOLAR LAVAGE; GROWTH-FACTOR; DISEASE; ALVEOLITIS; DETERMINANTS; PROGRESSION; APPEARANCES; CLEARANCE; SERUM;
D O I
10.1164/ajrccm.155.1.9001320
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Alkaline phosphatase (ALP) in lung lavage fluids is a marker of tissue damage and type II cell proliferation. Type II pneumocytes are extensively involved in fibrosis. The aim of our study was to verify whether local ALP activity can be held as a marker of fibrosis in chronic interstitial lung disorders. ALP was determined in the bronchoalveolar lavage of 140 subjects: 25 control subjects, and 33 patients with silicosis, 38 with idiopathic pulmonary fibrosis (IPF), and 18 with Stage I, 16 with Stage II and 10 with Stage III/IV sarcoidosis. We observed a significant augmentation of ALP activity in patients with IPF, as well as in those with Stages II and III/IV sarcoidosis. Albumin was higher in those with Stages I and II sarcoidosis, but it was normal in the other groups. Therefore, a significant increase in ALP:albumin ratio characterized IPF (median, 10.3; range, 2.4 to 83.2) and Stage III/IV sarcoidosis, (8.9, 4.4 to 103.1) as compared with Stage I (2, 1.1 to 18) and Stage II (4.7, 0.7 to 26.6) sarcoidosis, silicosis (6.5, 0.5 to 42.7), and the nonsmoker (6.1, 2.9 to 12.9) and smoker (6.4, 2 to 15.2) control groups. We conclude that an increase of the ALP: albumin ratio in bronchoalveolar lavage fluids from patients with chronic interstitial disorders may reflect a fibrosing progression.
引用
收藏
页码:249 / 253
页数:5
相关论文
共 32 条
[1]   CLINICAL AND FUNCTIONAL ASSESSMENT OF PATIENTS WITH IDIOPATHIC PULMONARY FIBROSIS - RESULTS OF A 3 YEAR FOLLOW-UP [J].
AGUSTI, C ;
XAUBET, A ;
AGUSTI, AGN ;
ROCA, J ;
RAMIREZ, J ;
RODRIGUEZROISIN, R .
EUROPEAN RESPIRATORY JOURNAL, 1994, 7 (04) :643-650
[2]  
BAUDOUIN SV, 1994, SARCOIDOSIS OTHER GR, P573
[3]  
BRIGGS DD, 1994, MKSAP PULMONARY MED, P148
[4]   INCREASED PROCOLLAGEN-III AMINOTERMINAL PEPTIDE-RELATED ANTIGENS AND FIBROBLAST GROWTH SIGNALS IN THE LUNGS OF PATIENTS WITH IDIOPATHIC PULMONARY FIBROSIS [J].
CANTIN, AM ;
BOILEAU, R ;
BEGIN, R .
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1988, 137 (03) :572-578
[5]  
CAPELLI A, 1993, CLIN CHEM, V39, P2201
[6]  
CAPELLI A, 1991, CHEST, V99, P545
[7]   CURRENT CONCEPTS IN IDIOPATHIC PULMONARY FIBROSIS - A ROAD MAP FOR THE FUTURE [J].
CHERNIACK, RM ;
CRYSTAL, RG ;
KALICA, AR .
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1991, 143 (03) :680-683
[8]  
*COMM ENZ SCAND SO, 1974, SCAND J CLIN LAB INV, V33, P291
[9]  
COSTABEL U, 1994, SARCOIDOSIS OTHER GR, P429
[10]   THE EPIDEMIOLOGY OF INTERSTITIAL LUNG-DISEASES [J].
COULTAS, DB ;
ZUMWALT, RE ;
BLACK, WC ;
SOBONYA, RE .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1994, 150 (04) :967-972