Effects of receptor class- and subtype-selective retinoids and an apoptosis-inducing retinoid on the adherent growth of the NIH:OVCAR-3 ovarian cancer cell line in culture

被引：42

作者：

Chao, WR

Hobbs, PD

Jong, L

Zhang, XK

Zheng, Y

Wu, Q

Shroot, B

Dawson, MI

机构：

[1] SRI INT,MENLO PK,CA 94025

[2] BURNHAM INST,LA JOLLA,CA 92037

[3] CIRD GALDERMA,VALBONNE,FRANCE

来源：

CANCER LETTERS | 1997年 / 115卷 / 01期

关键词：

AHPN; ovarian cancer cell growth inhibition; retinoid receptors;

D O I：

10.1016/S0304-3835(97)04598-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Comparison of the adherent growth inhibition of NIH:OVCAR-3 ovarian cancer cells by retinoid receptor class-selective and subtype-selective compounds with their receptor binding affinities and transcriptional activation activities indicated no correlation for RAR alpha and RAR gamma although both receptors are present. Retinoids that activated RXR alpha inhibited cell growth in the range as all-trans-retinoic acid and 9-cis-retinoic acid. The most potent inhibitor was 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic acid (AHPN), which has been found to inhibit breast and lung cancer and leukemia cell growth and induce cancer cell apoptosis through a pathway independent of the retinoid receptors. (C) 1997 Elsevier Science Ireland Ltd.

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页码：1 / 7

页数：7

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